Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
J Ethnopharmacol. 2024 Jan 10;318(Pt B):117000. doi: 10.1016/j.jep.2023.117000. Epub 2023 Aug 6.
Eriocephalus africanus infusion is used as a diuretic and a diaphoretic and is also used in the treatment of gastrointestinal disorders and gynaecological conditions, inflammation and dermal disorders, asthma, coughs, fevers, and painful ailments. The plant has been used traditionally as a medication to cure inflammation and skin problems.
Studying E. africanus essential oil (EAEO) as a potential hepatoprotective measure against concanavalin (Con) A-induced hepatitis in mice and investigating its underlying mechanism.
Hydro-distilled oil of the fresh plant aerial shoots is subjected to GC/MS analysis. Autoimmune hepatitis (AIH) was induced in mice by intravenous injection of Con A (15 mg/kg). EAEO was administered orally before Con A injection to test its hepatoprotective activity.
GC/MS analysis revealed the presence of 22 compounds representing 99.43% of the oil components. The monoterpene artemisia ketone (41.02%) and the sesquiterpene juniper camphor (14.17%) are the major components. The in vivo study showed that the oil suppressed Con A-induced neutrophil and CD4+T cell infiltration into the liver, restored hepatic redox balance, inhibited Con A-induced elevation of tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and interferon-gamma (IFN-γ) hepatic levels which were correlated with its ability to suppress nuclear factor kappa B (NF-κB) and Signal Transducer and Activator of Transcription (STAT1) activation in the liver.
EAEO showed hepatoprotective potential against Con A-induced hepatitis in mice collectively through selective anti-oxidant, anti-inflammatory, and anti-necrotic effects.
非洲蜡菊的浸剂被用作利尿剂和发汗剂，也用于治疗胃肠道疾病和妇科疾病、炎症和皮肤疾病、哮喘、咳嗽、发烧以及疼痛疾病。该植物传统上被用作治疗炎症和皮肤问题的药物。
研究非洲蜡菊精油（EAEO）作为一种潜在的肝保护措施，以对抗伴刀豆球蛋白 A（Con A）诱导的小鼠肝炎，并探讨其潜在机制。
对新鲜植物地上茎的水蒸馏油进行 GC/MS 分析。通过静脉注射 Con A（15mg/kg）在小鼠中诱导自身免疫性肝炎（AIH）。在注射 Con A 之前，通过口服给予 EAEO 以测试其肝保护活性。
GC/MS 分析显示存在 22 种化合物，占油成分的 99.43%。单萜青蒿酮（41.02%）和倍半萜杜松醇（14.17%）是主要成分。体内研究表明，该油抑制了 Con A 诱导的中性粒细胞和 CD4+T 细胞浸润到肝脏，恢复了肝脏的氧化还原平衡，抑制了 Con A 诱导的肿瘤坏死因子-α（TNF-α）、白细胞介素（IL-6）和干扰素-γ（IFN-γ）在肝脏中的水平升高，这与其抑制核因子 kappa B（NF-κB）和信号转导和转录激活因子（STAT1）在肝脏中的激活能力相关。
EAEO 对 Con A 诱导的小鼠肝炎具有潜在的肝保护作用，这是通过选择性抗氧化、抗炎和抗坏死作用实现的。
