Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine.
Department of Applied Information Engineering, Faculty of Engineering, Suwa University of Science.
Kurume Med J. 2023 Sep 25;68(3.4):209-220. doi: 10.2739/kurumemedj.MS6834012. Epub 2023 Aug 7.
Patients with cancer were able to live longer due to improvements in cancer treatment. Additionally, cardiovascular disease (CVD) is the second leading cause of mortality in cancer survivors. However, epidemiological data on onco-CVD have not been sufficiently provided. We aimed to investigate the clinical characteristics of cancer in CVD patients using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB).
The NDB sampling dataset used in this study was randomly sampled 10% from the whole Diagnosis Procedure Combination (DPC) records from every January, April, July, and October from 2011 to 2015. The significance of the increase trend in the percentage of records in each disease group to the total number of all DPC records from 2011 to 2015 was checked with Chi-square test with a Bonferroni correction. The percentage of records in cancer with the CVD group to the total number of all DPC records significantly increased over time, and their average age also increased since 2011. Their proportion over 75 years was approximately 56 % in 2015. There was no difference in the cancer sites. However, the prevalence of heart failure dramatically elevated.
We were able to assess the increase in cancer among CVD patients using DPC inpatient records obtained from the NDB. Both cardiologists and oncologists should be more aware of this phenomenon.
由于癌症治疗的进步，癌症患者的寿命得以延长。此外，心血管疾病（CVD）是癌症幸存者的第二大死亡原因。然而，关于肿瘤心血管疾病的流行病学数据尚未充分提供。我们旨在使用日本国民健康保险索赔和特定健康检查数据库（NDB）调查 CVD 患者中癌症的临床特征。
本研究使用的 NDB 抽样数据集是从 2011 年至 2015 年 1 月、4 月、7 月和 10 月每个月的所有诊断程序组合（DPC）记录中随机抽取的 10%。使用卡方检验（Bonferroni 校正）检查每种疾病组的记录百分比相对于 2011 年至 2015 年所有 DPC 记录总数的增加趋势的显著性。与心血管疾病组相关的癌症记录百分比相对于所有 DPC 记录的总数随着时间的推移显著增加，并且自 2011 年以来，其平均年龄也有所增加。2015 年，75 岁以上的比例约为 56%。癌症部位没有差异。然而，心力衰竭的患病率显著升高。
我们能够使用从 NDB 获得的 DPC 住院记录评估 CVD 患者中癌症的增加。心脏病专家和肿瘤学家都应该更加意识到这种现象。
