血清 NGAL 和β2 微球蛋白在急性胰腺炎和急性肾损伤患者血液和尿液中的预测价值。

Predictive Value of Serum NGAL and β2 Microglobulin in Blood and Urine amongst Patients with Acute Pancreatitis and Acute Kidney Injury.

机构信息

Department of Gastroenterology, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, 225001 Yangzhou, Jiangsu, China.

Department of Gastroenterology, Taizhou Central Hospital (Taizhou University Hospital), 318000 Taizhou, Zhejiang, China.

出版信息

Arch Esp Urol. 2023 Jul;76(5):335-340. doi: 10.56434/j.arch.esp.urol.20237605.39.

DOI:10.56434/j.arch.esp.urol.20237605.39

PMID:37545152

Abstract

OBJECTIVE

This study aimed to explore the predictive value of neutrophil gelatinase-associated lipocalin (NGAL) and β2 microglobulin (β2-MG) in blood and urine amongst patients with acute pancreatitis (AP) and acute kidney injury (AKI).

METHODS

The clinical data of 80 patients with AP, who were treated in the study hospital from November 2019, to November 2022, were selected for retrospective analysis. They were divided into AKI group (n = 25) and non-AKI group (n = 55) in accordance with the presence of AKI. The levels of serum NGAL and β2-MG in blood and urine were compared in both groups. Logistic regression analysis was used to explore the influencing factors of AKI in patients with AP and the receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of serum NGAL and β2-MG in the blood and urine of patients with AKI and AP.

RESULTS

The AKI group had higher serum NGAL and β2-MG in blood and urine than the non-AKI group. Logistic regression analysis showed that the high levels of serum NGAL and β2-MG in blood and urine were risk factors for AKI in patients with AP ( < 0.05). The areas under the curve (AUC), sensitivity and specificity of the combined prediction were 0.97, 84.00% and 98.20%, respectively, showing a good prediction efficiency.

CONCLUSIONS

The increased levels of serum NGAL and β2-MG in blood and urine have a warning significance for patients with AP and AKI and a certain predictive value. So, their combination detection provides a reliable reference for the identification of clinical AKI.

摘要

目的

本研究旨在探讨急性胰腺炎（AP）和急性肾损伤（AKI）患者血液和尿液中中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和β2 微球蛋白（β2-MG）的预测价值。

方法

回顾性分析 2019 年 11 月至 2022 年 11 月在我院治疗的 80 例 AP 患者的临床资料，将其分为 AKI 组（n=25）和非 AKI 组（n=55）。比较两组患者血液和尿液中血清 NGAL 和 β2-MG 水平。采用 Logistic 回归分析探讨 AP 患者 AKI 的影响因素，采用受试者工作特征（ROC）曲线评估血清 NGAL 和 β2-MG 对 AKI 患者的预测效果。

结果

AKI 组患者血液和尿液中血清 NGAL 和 β2-MG 水平均高于非 AKI 组。Logistic 回归分析显示，血液和尿液中血清 NGAL 和 β2-MG 水平升高是 AP 患者 AKI 的危险因素（<0.05）。联合预测的曲线下面积（AUC）、敏感度和特异度分别为 0.97、84.00%和 98.20%，具有较好的预测效率。