sFRP1 的上调在雌性 5xFAD 小鼠中比雄性更为显著，且与淀粉样蛋白病理学呈正相关。
Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology.
机构信息
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
出版信息
J Alzheimers Dis. 2023;95(2):399-405. doi: 10.3233/JAD-230218.
Abstract
The prevalence of Alzheimer's disease is greater in women, but the underlying mechanisms remain to be elucidated. We herein demonstrated that α-secretase ADAM10 was downregulated and ADAM10 inhibitor sFRP1 was upregulated in 5xFAD mice. While there were no sex effects on ADAM10 protein and sFRP1 mRNA levels, female 5xFAD and age-matched non-transgenic mice exhibited higher levels of sFRP1 protein than corresponding male mice. Importantly, female 5xFAD mice accumulated more Aβ than males, and sFRP1 protein levels were positively associated with Aβ42 levels in 5xFAD mice. Our study suggests that sFRP1 is associated with amyloid pathology in a sex-dependent manner.
摘要
阿尔茨海默病的患病率在女性中更高，但潜在机制仍有待阐明。我们在此证明，在 5xFAD 小鼠中 α-分泌酶 ADAM10 下调，ADAM10 抑制剂 sFRP1 上调。虽然 ADAM10 蛋白和 sFRP1 mRNA 水平没有性别影响，但雌性 5xFAD 和年龄匹配的非转基因小鼠的 sFRP1 蛋白水平高于相应的雄性小鼠。重要的是，雌性 5xFAD 小鼠比雄性小鼠积累了更多的 Aβ，并且 sFRP1 蛋白水平与 5xFAD 小鼠中的 Aβ42 水平呈正相关。我们的研究表明，sFRP1 以性别依赖的方式与淀粉样蛋白病理学相关。
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