Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Henan, China.
J Alzheimers Dis. 2023;95(2):523-533. doi: 10.3233/JAD-230253.
Studies have reported the associations between inflammation, brain volume, and cognition separately. It is reasonable to assume peripheral inflammation may contribute to cognitive decline through brain volume atrophy.
To examine the associations between peripheral inflammation, brain volume, and cognition among adults, and to investigate whether brain volume atrophy mediates the inflammation-cognition relationshipMethods:We retrieved 20,381 participants with available data on peripheral inflammation, brain volume, and cognition from the UK Biobank cohort. Cognitive function was assessed by performance on cognitive tasks probing various cognitive domains. Brain volumes were measured by magnetic resonance imaging (MRI). Multivariable linear models were used to investigate the associations between three peripheral inflammatory indexes (C-reactive protein, systemic immune-inflammatory index, neutrophil-to-lymphocyte ratio), brain volume, and cognition. Mediation analyses were conducted to assess the potential mediating effect of brain volume atrophy. All results were corrected for multiple comparisons using the false-discovery rate (FDR).
Peripheral inflammation was inversely associated with grey matter volume (GMV), white matter volume (WMV), and cognition after adjusting for potential covariates. For instance, CRP was associated with the GMV of left parahippocampal gyrus (β= -0.05, 95% confidence interval [CI]: -0.06 to -0.04, pFDR =1.07×10-16) and general cognitive factor (β= -0.03, 95% CI: -0. -0.04 to -0.01, pFDR = 0.001). Brain volume atrophy mediated the inflammation-cognitive decline relationship, accounting for 15-29% of the overall impact.
In this cohort study, peripheral inflammation was associated with brain volume atrophy and cognitive decline. Brain atrophy may mediate the inflammation-cognitive decline relationship.
已有研究分别报道了炎症、脑容量与认知之间的关联。合理的假设是外周炎症可能通过脑容量萎缩导致认知能力下降。
本研究旨在探讨成年人外周炎症、脑容量与认知之间的关系，并探讨脑容量萎缩是否介导了炎症与认知之间的关系。
我们从英国生物库队列中检索了 20381 名有外周炎症、脑容量和认知数据的参与者。认知功能通过认知任务的表现进行评估，这些认知任务探查了各种认知领域。脑容量通过磁共振成像（MRI）进行测量。多变量线性模型用于研究三种外周炎症指标（C 反应蛋白、全身免疫炎症指数、中性粒细胞与淋巴细胞比值）、脑容量与认知之间的关系。采用中介分析评估脑容量萎缩的潜在中介作用。所有结果均使用错误发现率（FDR）进行了多次比较校正。
在校正了潜在的混杂因素后，外周炎症与灰质体积（GMV）、白质体积（WMV）和认知呈负相关。例如，CRP 与左侧海马旁回的 GMV 呈负相关（β=-0.05，95%置信区间[CI]：-0.06 至-0.04，pFDR=1.07×10-16）和一般认知因子（β=-0.03，95% CI：-0.04 至-0.01，pFDR=0.001）。脑容量萎缩介导了炎症与认知下降之间的关系，占总体影响的 15-29%。
在这项队列研究中，外周炎症与脑容量萎缩和认知下降有关。脑萎缩可能介导了炎症与认知下降之间的关系。
