Pathology Queensland, Department of Anatomical Pathology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Diagn Cytopathol. 2023 Nov;51(11):E317-E321. doi: 10.1002/dc.25210. Epub 2023 Aug 6.
Adenoid cystic carcinoma (ACC) is an uncommon tumour that represents 5%-10% of salivary gland tumours and 1% of all head and neck malignancies. It is characterised by a protracted clinical course with late metastasis and poor long-term prognosis. We report the case of a 38-year-old woman presenting with pulmonary and pleural metastases, on the background of ACC of the floor of mouth, which had been treated 4 years ago with surgical excision and radiotherapy. Cytological evaluation of the pleural effusion showed exfoliated ACC tumour cells. Despite palliative chemotherapy, the patient developed disease progression including metastatic spread to the pericardium, and died of disease within a year. This case illustrates an unusual presentation of ACC and highlights the importance of considering this entity when encountering a basaloid neoplasm in extra-salivary locations.
腺样囊性癌（ACC）是一种罕见的肿瘤，占唾液腺肿瘤的 5%-10%，占头颈部恶性肿瘤的 1%。其特点是临床病程较长，晚期转移，长期预后差。我们报告了一例 38 岁女性患者，4 年前因口腔底的 ACC 接受了手术切除和放疗，现出现肺和胸膜转移。胸腔积液的细胞学评估显示有脱落的 ACC 肿瘤细胞。尽管进行了姑息性化疗，但患者的病情仍进展，包括转移性心包扩散，并在一年内死于疾病。本例说明了 ACC 的一种不常见表现，并强调了在遇到位于唾液腺外的基底样肿瘤时，考虑到这一实体的重要性。
