Falkson G, Gelman R S, Pretorius F J
J Clin Oncol. 1986 May;4(5):663-71. doi: 10.1200/JCO.1986.4.5.663.
The effect of age as a prognostic factor in recurrent breast cancer was studied in 1,168 patients treated on Eastern Cooperative Oncology Group (ECOG) protocols. Survival was significantly shorter in patients less than 35 years of age (P = .03). This was true even when other good prognostic factors were present. Eighteen prognostic factors were analyzed, and the effect on survival in each of six age groups was studied. Patients with better performance status, less than three sites of metastases, and without visceral or nodal metastases had a better survival time. A Cox proportional hazards model of survival showed that younger age groups, irrespective of menopausal status, had shorter survival times. The predicted median survival times after the first recurrence were 491 days for patients less than 35 years of age, 590 days for patients 36 to 45 years of age, and 700 days for those greater than 45 years of age.
在东部肿瘤协作组（ECOG）方案治疗的1168例复发性乳腺癌患者中，研究了年龄作为预后因素的影响。年龄小于35岁的患者生存期明显较短（P = 0.03）。即使存在其他良好的预后因素，情况也是如此。分析了18个预后因素，并研究了其对六个年龄组中每组患者生存的影响。身体状况较好、转移部位少于三处且无内脏或淋巴结转移的患者生存期更长。Cox生存比例风险模型显示，无论绝经状态如何，较年轻的年龄组生存期较短。首次复发后的预测中位生存期，年龄小于35岁的患者为491天，36至45岁的患者为590天，大于45岁的患者为700天。
