Wu Dengchang, Jiang Lin, He Runyang, Chen Baodan, Yao Dezhong, Wang Kang, Xu Peng, Li Fali
Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Front Neurol. 2023 Jul 20;14:1163772. doi: 10.3389/fneur.2023.1163772. eCollection 2023.
Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is autoimmune encephalitis with a characteristic neuropsychiatric syndrome and persistent cognition deficits even after clinical remission. The objective of this study was to uncover the potential noninvasive and quantified biomarkers related to residual brain distortions in convalescent anti-NMDARE patients.
Based on resting-state electroencephalograms (EEG), both power spectral density (PSD) and brain network analysis were performed to disclose the persistent distortions of brain rhythms in these patients. Potential biomarkers were then established to distinguish convalescent patients from healthy controls.
Oppositely configured spatial patterns in PSD and network architecture within specific rhythms were identified, as the hyperactivated PSD spanning the middle and posterior regions obstructs the inter-regional information interactions in patients and thereby leads to attenuated frontoparietal and frontotemporal connectivity. Additionally, the EEG indexes within delta and theta rhythms were further clarified to be objective biomarkers that facilitated the noninvasive recognition of convalescent anti-NMDARE patients from healthy populations.
Current findings contributed to understanding the persistent and residual pathological states in convalescent anti-NMDARE patients, as well as informing clinical decisions of prognosis evaluation.
抗N-甲基-D-天冬氨酸受体脑炎（抗NMDARE）是一种自身免疫性脑炎，具有特征性神经精神综合征，即使在临床缓解后仍存在持续的认知缺陷。本研究的目的是揭示与抗NMDARE恢复期患者残留脑功能异常相关的潜在非侵入性定量生物标志物。
基于静息态脑电图（EEG），进行功率谱密度（PSD）和脑网络分析，以揭示这些患者脑节律的持续异常。然后建立潜在生物标志物，以区分恢复期患者和健康对照。
在特定节律中，PSD和网络结构呈现相反的空间模式，即横跨中后区域的PSD过度激活阻碍了患者区域间的信息交互，从而导致额顶叶和额颞叶连接减弱。此外，δ波和θ波节律内的EEG指标进一步明确为客观生物标志物，有助于从健康人群中无创识别抗NMDARE恢复期患者。
目前的研究结果有助于理解抗NMDARE恢复期患者的持续和残留病理状态，并为预后评估的临床决策提供依据。
