Department of Medicine, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
Afr Health Sci. 2023 Mar;23(1):592-595. doi: 10.4314/ahs.v23i1.62.
Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report a case of TTP in a Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features of TTP resolved soon after clopidogrel was withdrawn. Clopidogrel is a cardio-protective anti-platelet drug used in CKD patients at risk of dyspepsia. However, its potential to cause TTP should be recognized and considered in acute kidney injury (AKI) patients previously on clopidogrel.
血栓性血小板减少性紫癜（TTP）是血栓性微血管病的一种罕见类型。我们报告了一例尼日利亚慢性肾脏病（CKD）患者发生 TTP 的病例，该患者此前曾服用氯吡格雷。停用氯吡格雷后，TTP 的特征很快得到缓解。氯吡格雷是一种用于有消化不良风险的 CKD 患者的心脏保护抗血小板药物。然而，对于先前服用氯吡格雷的急性肾损伤（AKI）患者，应认识到并考虑氯吡格雷导致 TTP 的可能性。
