1-甲基-1,4-雄甾二烯-3,17-二酮（SH 489）：一种雌激素生物合成不可逆抑制剂的特性研究
1-Methyl-1,4-androstadiene-3,17-dione (SH 489): characterization of an irreversible inhibitor of estrogen biosynthesis.
作者信息
Henderson D, Norbisrath G, Kerb U
出版信息
J Steroid Biochem. 1986 Jan;24(1):303-6. doi: 10.1016/0022-4731(86)90069-5.
PMID:3754599
Abstract
1-Methyl-1,4-androstadiene-3,17-dione (SH 489) was characterized as a competitive and irreversible inhibitor of human placental aromatase. The compound and the principal predicted metabolites show no endocrinological side effects suggesting that SH 489 should be suitable as a prototype drug for treatment of estrogen-dependent disease states.
摘要
1-甲基-1,4-雄甾二烯-3,17-二酮（SH 489）被鉴定为人类胎盘芳香化酶的竞争性不可逆抑制剂。该化合物及其主要预测代谢产物未显示出内分泌副作用，这表明SH 489应适合作为治疗雌激素依赖性疾病状态的原型药物。
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