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一例经手术切除、化疗及外照射放疗治疗的难治性阴茎鳞状细胞癌病例报告。

A Case Report of Refractory Penile Squamous Cell Carcinoma Treated With Surgical Resection, Chemotherapy and External Beam Radiation Therapy.

作者信息

Zong Perry, Garlapati Jay, Miller Steven

机构信息

Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, USA.

出版信息

Cureus. 2023 Jul 4;15(7):e41358. doi: 10.7759/cureus.41358. eCollection 2023 Jul.

DOI:10.7759/cureus.41358
PMID:37546144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10399608/
Abstract

Penile cancer is a rare cancer in developed nations, with metastatic disease seen in under 10% of cases at presentation. Treatment is multimodal and dependent on tumor stage, risk of recurrence, nodal involvement, and advancement of the disease. We report a case of a 49-year-old male with penile squamous cell carcinoma, who initially presented with a penile lesion but became lost to follow-up due to the coronavirus disease 2019 (COVID-19) pandemic. Therapies included surgical resection, chemotherapy, and external beam radiation therapy. His disease course was additionally complicated by its aggressive nature, poor response to first-line chemotherapy, and secondary nosocomial infections.

摘要

阴茎癌在发达国家是一种罕见癌症,就诊时转移性疾病在不到10%的病例中出现。治疗是多模式的,取决于肿瘤分期、复发风险、淋巴结受累情况以及疾病进展程度。我们报告一例49岁男性阴茎鳞状细胞癌病例,该患者最初表现为阴茎病变,但因2019冠状病毒病(COVID-19)大流行而失访。治疗方法包括手术切除、化疗和外照射放疗。其病程还因其侵袭性、对一线化疗反应不佳以及继发性医院感染而更加复杂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/f24c485aeb75/cureus-0015-00000041358-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/05302c52ae04/cureus-0015-00000041358-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/22c8590302e9/cureus-0015-00000041358-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/cd8473666606/cureus-0015-00000041358-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/161f23d40f8c/cureus-0015-00000041358-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/671a2bc7f3fe/cureus-0015-00000041358-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/f24c485aeb75/cureus-0015-00000041358-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/05302c52ae04/cureus-0015-00000041358-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/22c8590302e9/cureus-0015-00000041358-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/cd8473666606/cureus-0015-00000041358-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/161f23d40f8c/cureus-0015-00000041358-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/671a2bc7f3fe/cureus-0015-00000041358-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1671/10399608/f24c485aeb75/cureus-0015-00000041358-i06.jpg

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本文引用的文献

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Penile carcinoma and HPV infection (Review).阴茎癌与HPV感染(综述)
Exp Ther Med. 2020 Jul;20(1):91-96. doi: 10.3892/etm.2019.8181. Epub 2019 Nov 11.
2
The Diagnosis and Treatment of Penile Cancer.阴茎癌的诊断与治疗。
Dtsch Arztebl Int. 2018 Sep 28;115(39):646-652. doi: 10.3238/arztebl.2018.0646.
3
Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery.阴茎鳞状细胞癌:文献综述及Mohs显微外科手术治疗病例报告
An Bras Dermatol. 2017 Jan-Feb;92(1):95-99. doi: 10.1590/abd1806-4841.20175009.