Islam Baharul, Colby David A
Department of BioMolecular Sciences, University of Mississippi, University, Mississippi, U.S.A.
J Fluor Chem. 2023 Aug;270. doi: 10.1016/j.jfluchem.2023.110162. Epub 2023 Jul 11.
Pentafluoro--diols have emerged as a source of reactive intermediates for synthesizing fluorinated molecules. When pentafluoro--diols were exposed to alcohols as solvents, the formation of transient hemiketals was detected by 19F NMR. The conversion rates to hemiketals were found to be higher with primary alcohols than with secondary or fluorinated alcohols. These findings provide valuable insight for developing novel techniques to construct intricate fluorinated structures using pentafluoro--diols.
五氟二醇已成为合成含氟分子的反应中间体来源。当五氟二醇暴露于作为溶剂的醇类中时，通过19F NMR检测到瞬态半缩酮的形成。发现伯醇形成半缩酮的转化率高于仲醇或氟化醇。这些发现为开发利用五氟二醇构建复杂含氟结构的新技术提供了有价值的见解。
