Betsholtz C, Johnsson A, Heldin C H, Westermark B, Lind P, Urdea M S, Eddy R, Shows T B, Philpott K, Mellor A L
Nature. 1986;320(6064):695-9. doi: 10.1038/320695a0.
The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
从互补DNA克隆中推导了人肿瘤细胞系来源的血小板衍生生长因子（PDGF）A链前体的氨基酸序列，并将该基因定位于7号染色体。该蛋白质与PDGF B链前体具有广泛的同源性。在许多人肿瘤细胞系中，PDGF A链基因的表达独立于PDGF B链，相对分子质量为31,000的类PDGF生长因子的分泌与A链而非B链信使RNA的表达相关。
