Wu Yue, Li An, Chen Can, Fang Zhang, Chen Lujun, Zheng Xiao
Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Front Oncol. 2023 Jul 20;13:1229168. doi: 10.3389/fonc.2023.1229168. eCollection 2023.
N-methyladenosine (mA) is the most prevalent internal modification found in both mRNA and lncRNA. It exerts reversible regulation over RNA function and affects RNA processing and metabolism in various diseases, especially tumors. The mA binding protein, hnRNPA2B1, is extensively studied as a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) protein family. It is frequently dysregulated and holds significant importance in multiple types of tumors. By recognizing mA sites for variable splicing, maintaining RNA stability, and regulating translation and transport, hnRNPA2B1 plays a vital role in various aspects of tumor development, metabolism, and regulation of the immune microenvironment. In this review, we summarized the latest research on the functional roles and underlying molecular mechanisms of hnRNPA2B1. Moreover, we discussed its potential as a target for tumor therapy.
N6-甲基腺苷（mA）是在信使核糖核酸（mRNA）和长链非编码核糖核酸（lncRNA）中发现的最普遍的内部修饰。它对RNA功能进行可逆调节，并影响多种疾病，尤其是肿瘤中的RNA加工和代谢。mA结合蛋白hnRNPA2B1作为异质性核糖核蛋白（hnRNP）家族的成员被广泛研究。它经常失调，在多种类型的肿瘤中具有重要意义。通过识别可变剪接的mA位点、维持RNA稳定性以及调节翻译和转运，hnRNPA2B1在肿瘤发生发展、代谢以及免疫微环境调节的各个方面发挥着至关重要的作用。在本综述中，我们总结了关于hnRNPA2B1功能作用及潜在分子机制的最新研究。此外，我们还讨论了其作为肿瘤治疗靶点的潜力。
