Djahandideh Sheijani Shirin, Calabrese Francesco, Pasta Andrea, Marabotto Elisa, Bodini Giorgia, Furnari Manuele, Grillo Federica, Mastracci Luca, Savarino Edoardo V, Savarino Vincenzo, Giannini Edoardo G
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
ACG Case Rep J. 2023 Aug 3;10(8):e01118. doi: 10.14309/crj.0000000000001118. eCollection 2023 Aug.
Eosinophilic colitis is a rare condition characterized by histologic findings of high eosinophilic infiltrate in the gut wall, typically presenting with diarrhea and abdominal pain. The etiology of this entity remains unclear because it can be primary or can occur secondarily to infections, drugs, or even in association with immune-mediated diseases. We present the case of a woman referred to our outpatient clinic for chronic diarrhea that had been worsening for months. Colonoscopy with biopsies was performed, and eosinophilic colitis associated with the use of clopidogrel was diagnosed. After clopidogrel discontinuation, a complete remission of the clinical and histological picture was observed.
嗜酸性粒细胞性结肠炎是一种罕见疾病，其特征为肠壁有大量嗜酸性粒细胞浸润的组织学表现，通常表现为腹泻和腹痛。该疾病的病因尚不清楚，因为它可以是原发性的，也可能继发于感染、药物，甚至与免疫介导性疾病有关。我们报告一例因慢性腹泻数月来病情逐渐加重而转诊至我院门诊的女性病例。进行了结肠镜检查及活检，诊断为与使用氯吡格雷相关的嗜酸性粒细胞性结肠炎。停用氯吡格雷后，临床和组织学表现完全缓解。
