Pang I H, Vasko M R
Brain Res. 1986 Apr 16;371(1):171-6. doi: 10.1016/0006-8993(86)90824-3.
We studied whether antinociception produced by injection of morphine into the nucleus reticularis paragigantocellularis (NRPG) or by superfusion onto the spinal cord involved norepinephrine (NE)-containing neurons that descend from brainstem into the spinal cord. Spinal cord NE concentrations were depleted with the neurotoxin, 6-hydroxydopamine, and antinociception was measured following morphine injection into NRPG or onto spinal cord. Depletion of cord NE by approximately 90% did not attenuate the antinociceptive effect of either 2 or 10 micrograms of morphine injected intrathecally. In contrast, the depletion did significantly attenuate the antinociceptive effect of 2.5 micrograms morphine injected bilaterally into the NRPG. These results suggest that NE-containing neurons descending from brainstem nuclei into the spinal cord are not important in the analgesia produced by injecting morphine directly onto the spinal cord but may be involved with analgesia produced by morphine injection into the NRPG.
我们研究了向巨细胞旁网状核（NRPG）注射吗啡或向脊髓灌注吗啡所产生的抗伤害感受是否涉及从脑干下行至脊髓的含去甲肾上腺素（NE）的神经元。用神经毒素6-羟基多巴胺耗尽脊髓中的NE浓度，然后在向NRPG注射吗啡或向脊髓灌注吗啡后测量抗伤害感受。脊髓NE浓度降低约90%并不会减弱鞘内注射2或10微克吗啡的抗伤害感受作用。相比之下，这种降低确实显著减弱了双侧向NRPG注射2.5微克吗啡的抗伤害感受作用。这些结果表明，从脑干核团下行至脊髓的含NE的神经元在直接向脊髓注射吗啡所产生的镇痛中并不重要，但可能参与了向NRPG注射吗啡所产生的镇痛。
