Jan K Y, Huang R Y, Lee T C
Cytogenet Cell Genet. 1986;41(4):202-8. doi: 10.1159/000132230.
Chromosomal aberrations induced by ethyl methanesulfonate (EMS) in Chinese hamster ovary cells were potentiated by subsequent exposure to sodium arsenite (AS), 3-aminobenzamide (3AB), or caffeine (CAF). The coclastogenicity of AS was most evident when this drug was applied for 3 or 6 h immediately after EMS was removed, whereas caffeine acted primarily after 12-18 h. The coclastogenicity of 3AB was not stage dependent. AS and 3AB increased chromatid exchanges more than chromatid breaks, whereas caffeine mainly increased chromatid breaks. Thus the coclastogenicities of AS, 3AB, and CAF differ in their time of action and the types of aberrations they potentiate.
甲磺酸乙酯（EMS）在中国仓鼠卵巢细胞中诱导的染色体畸变，会因随后暴露于亚砷酸钠（AS）、3-氨基苯甲酰胺（3AB）或咖啡因（CAF）而增强。当在去除EMS后立即应用AS 3或6小时时，其协同致断裂性最为明显，而咖啡因主要在12 - 18小时后起作用。3AB的协同致断裂性不依赖阶段。AS和3AB增加的染色单体交换多于染色单体断裂，而咖啡因主要增加染色单体断裂。因此，AS、3AB和CAF的协同致断裂性在作用时间和它们增强的畸变类型方面存在差异。
