Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
J Int Med Res. 2023 Aug;51(8):3000605231184046. doi: 10.1177/03000605231184046.
To explore the association between the controlling nutritional status (CONUT) score and disease activity in patients with ulcerative colitis (UC).
This retrospective study enrolled patients with UC. Demographic, clinical and laboratory data were collected and compared. The CONUT score was obtained for each patient. The association between the CONUT score and laboratory parameters was analysed and the ability of the score to assess disease activity was evaluated.
A total of 182 patients with UC were enrolled. Patients with active disease showed significantly increased inflammatory biomarkers and decreased nutritional biomarkers compared with patients in remission. Malnourished individuals had significantly elevated inflammatory biomarkers and significantly reduced haemoglobin, prealbumin and retinol-binding protein. The CONUT score was inversely correlated with haemoglobin, prealbumin, retinol-binding protein and was positively correlated with faecal calprotectin, C-reactive protein, erythrocyte sedimentation rate, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. The area under the receiver operating characteristic curve was 0.655 (95% confidence interval, 0.557-0.752). The optimal cut-off value was 1.5 points, with a sensitivity of 75.7% and a specificity of 50.0%.
The CONUT score may evaluate the inflammatory response and nutritional status of UC patients, so it could be a potential biomarker to assess disease activity in UC.
探讨控制营养状况（CONUT）评分与溃疡性结肠炎（UC）患者疾病活动度的关系。
本回顾性研究纳入了 UC 患者。收集并比较了患者的人口统计学、临床和实验室数据。为每位患者计算 CONUT 评分。分析了评分与实验室参数之间的关联，并评估了评分评估疾病活动度的能力。
共纳入 182 例 UC 患者。与缓解期患者相比，活动期患者的炎症生物标志物显著升高，营养生物标志物显著降低。营养不良患者的炎症生物标志物显著升高，血红蛋白、前白蛋白和视黄醇结合蛋白显著降低。CONUT 评分与血红蛋白、前白蛋白和视黄醇结合蛋白呈负相关，与粪便钙卫蛋白、C 反应蛋白、红细胞沉降率、中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值呈正相关。受试者工作特征曲线下面积为 0.655（95%置信区间，0.557-0.752）。最佳截断值为 1.5 分，灵敏度为 75.7%，特异性为 50.0%。
CONUT 评分可评估 UC 患者的炎症反应和营养状况，因此可能是评估 UC 疾病活动度的潜在生物标志物。
