Lechner A J, Winston D C, Bauman J E
J Appl Physiol (1985). 1986 May;60(5):1610-4. doi: 10.1152/jappl.1986.60.5.1610.
Prenatal starvation in the guinea pig causes reduced pulmonary diffusing capacity and retarded alveolarization among neonates. To study the impact of such starvation on biochemical and mechanical properties of the neonatal lung, pregnant guinea pigs were fed ad libitum throughout gestation or starved with 50% rations during their last trimester. Neonatal body weight was 35% less due to starvation, and dry lung weight, DNA, and protein contents were decreased 26, 36, and 31%, respectively (P less than 0.001 for all). Hematological data indicated no anemia, hypoproteinemia, or altered glucocorticoid levels due to starvation. Total surfactant phospholipids in these neonates were reduced 61% in lavage and 35% in the neonatal lung tissue, although surfactant compositions were similar to controls. Specific lung compliance in the air-filled lungs was not altered, but the saline-filled lungs were more distensible over deflation pressures of 9-18 cmH2O (transpulmonary). Although starvation retarded both lung cellularity and surfactant, only that portion of lung elastic recoil attributable to tissue forces was affected.
豚鼠产前饥饿会导致新生儿肺扩散能力降低和肺泡化延迟。为研究这种饥饿对新生儿肺生化和力学特性的影响，将妊娠豚鼠在整个妊娠期自由采食，或在妊娠晚期给予50%的定量食物使其饥饿。饥饿导致新生儿体重降低35%，肺干重、DNA和蛋白质含量分别降低26%、36%和31%（所有均P<0.001）。血液学数据表明，饥饿未导致贫血、低蛋白血症或糖皮质激素水平改变。这些新生儿灌洗中的总表面活性物质磷脂减少61%，新生儿肺组织中减少35%，尽管表面活性物质组成与对照组相似。充气肺的比肺顺应性未改变，但在9-18 cmH2O（跨肺）的放气压力下，充生理盐水的肺更易扩张。尽管饥饿会延迟肺细胞生成和表面活性物质生成，但仅肺弹性回缩中归因于组织力的部分受到影响。
