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运动作为治疗血脂异常(和其他危险因素)的药物。

Sport as Medicine for Dyslipidemia (and Other Risk Factors).

机构信息

University of Medicine and Pharmacy "Victor Babes" Timisoara, Timișoara, Romania.

Institute for Cardiovascular Diseases Timisoara, Research Center IBCVTIM, Timișoara, Romania.

出版信息

Curr Atheroscler Rep. 2023 Sep;25(9):613-617. doi: 10.1007/s11883-023-01133-y. Epub 2023 Aug 7.

Abstract

PURPOSE OF REVIEW

Dyslipidemia is a common condition characterized by abnormal lipid levels in the blood, which can increase the risk of cardiovascular disease. Physical activity and participation in sports have been shown to have a positive impact on lipid profiles and reduce the risk of dyslipidemia. Additionally, regular physical activity can lead to weight loss and improved insulin sensitivity, both of which are associated with improved lipid profiles. This review aims to provide an overview on the utility of physical activity in the management of dyslipidemia.

RECENT FINDINGS

Improvements in lipid profiles were observed across both short- and long-term durations of high-intensity interval training (HIIT) and moderate intensity interval training (MIIT). However, it seems that more significant improvements in lipid profiles can be achieved with longer periods of physical activity and more intense exercise regimens. Several studies have investigated the relationship between aerobic exercise and HDL cholesterol (HDL-C), and the results suggest that HDL-C levels are more responsive to aerobic exercise compared to LDL cholesterol (LDL-C) and triglycerides (TG). Although findings on the effect of aerobic exercise on LDL-C levels have been inconsistent, there may still be beneficial changes in LDL-C subfractions that could provide cardiovascular protection. One such subfraction is plasma Lp(a), which contains Apo(a). However, unlike other LDL subfractions, Lp(a) is determined by genetics and is not influenced by physical activity. Therefore, it cannot be improved through exercise. Exercise is commonly believed to lead to a decrease in plasma TG concentrations. However, it is important to note that the baseline TG level may play a crucial role in determining the effect of exercise on the TG response. Factors such as individual variability and metabolic differences can influence the response of TG levels to exercise. Overall, exercise plays a crucial role in improving lipid profiles and promoting cardiovascular health. In conclusion, sport can be considered a form of medicine for dyslipidemia. Regular physical activity and participation in sports can improve lipid profiles, reduce the risk of cardiovascular disease, and improve overall health. It is essential to incorporate exercise and a healthy lifestyle into one's daily routine to prevent and manage dyslipidemia effectively.

摘要

目的综述

血脂异常是一种常见病症,其特征是血液中脂质水平异常,这会增加心血管疾病的风险。运动和参与体育运动已被证明对脂质谱有积极影响,并降低血脂异常的风险。此外,定期运动可以导致体重减轻和改善胰岛素敏感性,这两者都与改善脂质谱有关。本篇综述旨在提供关于运动在血脂异常管理中的应用的概述。

最近发现

在高强度间歇训练(HIIT)和中等强度间歇训练(MIIT)的短期和长期内,脂质谱都得到了改善。然而,似乎通过更长时间的运动和更剧烈的运动方案可以实现脂质谱的更大改善。一些研究调查了有氧运动与高密度脂蛋白胆固醇(HDL-C)之间的关系,结果表明与 LDL-C 和甘油三酯(TG)相比,HDL-C 水平对有氧运动更敏感。尽管关于有氧运动对 LDL-C 水平的影响的研究结果不一致,但 LDL-C 亚组分仍可能发生有益的变化,从而提供心血管保护。其中一个亚组分是载脂蛋白(Apo)a 含量较高的脂蛋白(a)。然而,与其他 LDL 亚组分不同,Lp(a) 由遗传决定,不受运动影响。因此,它不能通过运动来改善。运动通常被认为会导致血浆 TG 浓度降低。然而,值得注意的是,基线 TG 水平可能在决定运动对 TG 反应的影响方面起着关键作用。个体差异和代谢差异等因素会影响 TG 水平对运动的反应。总的来说,运动在改善脂质谱和促进心血管健康方面起着关键作用。总之,运动可以被视为血脂异常的一种治疗方法。定期运动和参与体育运动可以改善脂质谱,降低心血管疾病的风险,并改善整体健康。将运动和健康的生活方式融入日常生活中对于有效预防和管理血脂异常至关重要。

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