Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Inflamm Bowel Dis. 2024 Jun 3;30(6):1009-1017. doi: 10.1093/ibd/izad159.
The concept of disease clearance has been proposed as a potential target in ulcerative colitis (UC). We conducted a systematic review to investigate the role of disease clearance, defined as a composite outcome including simultaneous clinical, endoscopic, and histologic remission of disease in the management of patients with UC. Based on the literature data, statements regarding disease clearance were developed and voted on by the members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) according to a Delphi methodology. A definition of disease clearance was proposed to standardize its use in clinical practice and clinical trials and to provide practical recommendations for its implementation as a therapeutic target in UC.
疾病缓解的概念已被提出作为溃疡性结肠炎（UC）的一个潜在目标。我们进行了一项系统综述，旨在研究疾病缓解（定义为同时达到临床、内镜和组织学疾病缓解的复合结局）在 UC 患者管理中的作用。根据文献数据，国际炎症性肠病研究组织（IOIBD）的成员采用德尔菲法制定并投票表决了关于疾病缓解的声明。提出了疾病缓解的定义，以规范其在临床实践和临床试验中的应用，并为将其作为 UC 的治疗目标提供实施的实用建议。
