Institut de génomique fonctionnelle , Université de Montpellier, INSERM, CNRS, 141 rue de la Cardonille, 34090, Montpellier, France.
Steroids. 2023 Nov;199:109294. doi: 10.1016/j.steroids.2023.109294. Epub 2023 Aug 6.
Glucocorticoids are stress hormones that play central roles in the immediate and slower adaptive responses of the brain and body to new behavioral experience. The exact mechanisms by which the rapid and slow processes underlying glucocorticoid mnemonic effects unfold are under intensive scrutiny. It is possible that glucocorticoids rapidly modify memory representations in the brain by interfering with synaptic functions between inhibitory and excitatory neurons in a timing and context dependent manner. In particular, activity-dependent trans-synaptic messengers appear to have all the necessary attributes to engage in the rapid signaling by glucocorticoids and regulate the brain and behaviors. Novel frameworks for the treatment of stress-related disorders could emerge from a better characterization of the dynamic interplay between the rapid and slow signaling components by glucocorticoids on large-scale brain networks. Here I present some of the exact factors that could help reach this objective.
糖皮质激素是应激激素，在大脑和身体对新的行为经验的即时和较慢的适应反应中发挥核心作用。糖皮质激素记忆效应的快速和缓慢过程的确切机制正在受到深入研究。糖皮质激素可能通过以时间和上下文依赖的方式干扰抑制性和兴奋性神经元之间的突触功能，快速改变大脑中的记忆表现。特别是，活性依赖性跨突触信使似乎具有参与糖皮质激素快速信号传递并调节大脑和行为的所有必要属性。通过糖皮质激素在大规模大脑网络上的快速和缓慢信号成分之间的动态相互作用的更好描述，可能会出现治疗与压力相关疾病的新框架。在这里，我提出了一些可能有助于实现这一目标的具体因素。
