Department of Chemical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, 81746-73441, Iran.
Department of Chemical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, 81746-73441, Iran.
Dent Mater. 2023 Oct;39(10):863-871. doi: 10.1016/j.dental.2023.07.010. Epub 2023 Aug 5.
The main aim of the current work was to develop dental acrylic-based composites with protein-repellent and antibacterial properties by using surface-modified silica nanoparticles. The effects of surface modification of silica nanoparticles in protein-repellent and antibacterial activity and mechanical properties of dental composites including flexural strength, flexural modulus, and hardness were discussed.
The surface of silica nanoparticles was first chemically treated with 3-methacryloxypropyltrimethoxysilane (MPS) as a coupling agent and then with poly(ethylene glycol) (PEG) bonded to MPS. Dental acrylic-based composites were prepared with mass fractions of 10, 15, 20, 30, and 40 % of PEG-modified MPS-silica nanoparticles (PMS). The chemical surface modification of silica nanoparticles with MPS and PEG was confirmed by Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA).
The dental composite containing 20 wt% PMS nanoparticles could reduce the protein adsorption by 28 % as compared with a composite containing 20 wt% MPS-modified silica. The antibacterial test indicated that the PMS nanoparticles can significantly reduce the adhesion of Streptococcus mutans and the biofilm formation on the surface of dental composites. It was found that the flexural strength increased by increasing the PMS nanoparticles from 0 to 20 wt% and then decreased by the incorporation of higher percentages of these nanoparticles. Also, with increasing the weight percentage of PMS nanoparticles, the elastic and the flexural modulus and the hardness of resin nanocomposites were increased.
In the current work, for the first time, dental resin composites containing PEG were prepared with excellent protein-repellent and antibacterial properties.
本研究旨在通过使用表面改性的硅纳米粒子开发具有抗蛋白和抗菌性能的牙科丙烯酸基复合材料。讨论了硅纳米粒子表面改性对牙科复合材料的抗蛋白和抗菌活性以及机械性能（包括弯曲强度、弯曲模量和硬度）的影响。
首先，通过 3-甲基丙烯酰氧基丙基三甲氧基硅烷（MPS）作为偶联剂对硅纳米粒子的表面进行化学处理，然后与键合到 MPS 上的聚乙二醇（PEG）进行反应。通过质量分数为 10、15、20、30 和 40%的 PEG 修饰的 MPS-硅纳米粒子（PMS）制备牙科丙烯酸基复合材料。通过傅里叶变换红外光谱（FTIR）和热重分析（TGA）确认硅纳米粒子的化学表面改性。
与含有 20wt%MPS 改性硅的复合材料相比，含有 20wt%PMS 纳米粒子的牙科复合材料的蛋白吸附量降低了 28%。抗菌试验表明，PMS 纳米粒子能显著减少变形链球菌的黏附以及其在牙科复合材料表面的生物膜形成。结果发现，随着 PMS 纳米粒子从 0 增加到 20wt%，弯曲强度增加，然后随着这些纳米粒子的比例增加而降低。此外，随着 PMS 纳米粒子重量百分比的增加，树脂纳米复合材料的弹性、弯曲模量和硬度均增加。
在本研究中，首次制备了具有优异抗蛋白和抗菌性能的含 PEG 的牙科树脂复合材料。
