Department of Orthopedics, The People's Hospital of Weifang, 151 Guangwen Street, Kuiwen District, Weifang, 261000, Shandong, China.
J Orthop Surg Res. 2023 Aug 7;18(1):575. doi: 10.1186/s13018-023-04056-1.
Current evidence of the association between a single nucleotide polymorphism (SNP) in ADAMTS14 (rs4747096) and osteoarthritis (OA) is controversial. This study aimed to determine whether the ADAMTS14 SNP is closely related to OA risk.
An electronic search of for the association between the rs4747096 polymorphisms and OA was performed using four online databases (updated on September 10, 2022). The association between susceptibility to OA and rs4747096 polymorphism was evaluated in four genetic models: the allele (mutation [A] vs. wild type [G]), additive (AA vs. GG and AG vs. GG), recessive (AA vs. AG + GG), and dominant (AA + AG vs. GG). This meta-analysis was performed in the R software, and effects were assessed using odds ratios (ORs) and 95% confidence intervals (CI).
Four studies (707 cases in the case group and 859 cases in the control group) were included. The results of the meta-analysis showed that, except in the recessive genetic model, there was a significant correlation between OA risk and the rs4747096 polymorphism using the allele (OR [95% CI] = 1.48 [1.26-1.73], P < 0.001), additive (AG vs. GG, OR [95% CI] = 2.56 [1.79-3.65], P < 0.001; AA vs. GG, OR [95% CI] = 2.81 [1.98-3.98], P < 0.001), and dominant (OR [95% CI)] = 1.72 [1.34-2.2], P < 0.001) genetic models.
The ADAMTS14 rs4747096 polymorphism is associated with susceptibility to OA.
目前关于 ADAMTS14（rs4747096）单核苷酸多态性与骨关节炎（OA）之间的关联的证据存在争议。本研究旨在确定 ADAMTS14 单核苷酸多态性是否与 OA 风险密切相关。
使用四个在线数据库（更新于 2022 年 9 月 10 日）对 rs4747096 多态性与 OA 之间的关联进行电子检索。采用四种遗传模型（突变 [A]与野生型 [G]的等位基因、AA 与 GG 和 AG 与 GG 的加性、AA 与 AG+GG 的隐性、AA+AG 与 GG 的显性）评估 rs4747096 多态性与 OA 易感性的关联。该荟萃分析在 R 软件中进行，使用比值比（ORs）和 95%置信区间（CIs）评估效应。
共纳入四项研究（病例组 707 例，对照组 859 例）。荟萃分析结果显示，除隐性遗传模型外，rs4747096 多态性与 OA 风险在等位基因（OR [95%CI] = 1.48 [1.26-1.73]，P<0.001）、加性（AG 与 GG，OR [95%CI] = 2.56 [1.79-3.65]，P<0.001；AA 与 GG，OR [95%CI] = 2.81 [1.98-3.98]，P<0.001）和显性（OR [95%CI] = 1.72 [1.34-2.2]，P<0.001）遗传模型中均存在显著相关性。
ADAMTS14 rs4747096 多态性与 OA 易感性相关。
