Engineering Research Center of Fungal Biotechnology, Ministry of Education; Research Center on Entomogenous Fungi, Anhui Agricultural University, Hefei, Anhui Province 230036, People's Republic of China.
Natural Products Laboratory, State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, Anhui Province 230036, People's Republic of China.
J Nat Prod. 2023 Aug 25;86(8):1885-1890. doi: 10.1021/acs.jnatprod.2c01097. Epub 2023 Aug 7.
Three new cyclic peptides, meristosporins A, B, and C (-), one of which features an unusual amino acid, were isolated from the opportunistic pathogen and identified by 1D, 2D NMR, MS/MS, and Marfey's analysis. The biosynthetic pathway of the hexapeptide meristosporin A () was deduced based on nonribosomal peptide synthetase gene clusters analysis. Compounds and showed cytotoxicity to RAW264.7 and 293T cells, respectively. These compounds may be involved in the fungal injury caused to human cells.
从机会性病原体中分离得到三个新的环肽，meristosporins A、B 和 C（-），其中一个具有不常见的氨基酸，并通过 1D、2D NMR、MS/MS 和 Marfey 分析进行了鉴定。基于非核糖体肽合成酶基因簇分析，推断出六肽 meristosporin A（）的生物合成途径。化合物和分别对 RAW264.7 和 293T 细胞表现出细胞毒性。这些化合物可能与真菌对人细胞造成的损伤有关。
