Wang L Y, Liang Q F
Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology & Visual Sciences,Beijing 100730,China.
Zhonghua Yan Ke Za Zhi. 2023 Aug 11;59(8):673-676. doi: 10.3760/cma.j.cn112142-20220917-00459.
Limbal stem cell deficiency (LSCD) is an ocular surface disease resulting from a reduction and/or dysfunction of limbal stem cells. The symptoms of LSCD are non-specific and can be difficult to distinguish from other ocular surface diseases through slit-lamp examination. Impression cytology is currently considered the gold standard for LSCD diagnosis; however,it is a qualitative method with low sensitivity. Nonetheless,emerging imaging techniques offer quantitative diagnosis and staging of LSCD. This review article examines four imaging methods and their associated parameters for diagnosing LSCD: optical coherence tomography,which measures corneal epithelial thickness; optical coherence tomography angiography,which detects corneal neovascularization; confocal microscopy,which measures corneal epithelial thickness,subbasal nerve density,and corneal basal cell density; and future applications of full-field/spectral-domain optical coherence tomography.
角膜缘干细胞缺乏症（LSCD）是一种由于角膜缘干细胞减少和/或功能障碍导致的眼表疾病。LSCD的症状不具有特异性，通过裂隙灯检查很难与其他眼表疾病区分开来。目前，印迹细胞学被认为是LSCD诊断的金标准；然而，它是一种定性方法，灵敏度较低。尽管如此，新兴的成像技术为LSCD的定量诊断和分期提供了可能。本文综述了四种用于诊断LSCD的成像方法及其相关参数：测量角膜上皮厚度的光学相干断层扫描；检测角膜新生血管的光学相干断层扫描血管造影；测量角膜上皮厚度、基底神经密度和角膜基底细胞密度的共聚焦显微镜；以及全场/光谱域光学相干断层扫描的未来应用。
