Department of Clinical Epidemiology and Biostatistics, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Clin Exp Hypertens. 2023 Dec 31;45(1):2243056. doi: 10.1080/10641963.2023.2243056.
Although nuts play an important role in preventing cardiovascular disease, the metabolic cues by which nuts regulate blood pressure have not been fully understood.Aims:We conducted a nested case-control study in a prospective cohort study of Southwest China children to explore the potential lipid metabolites related to the relationship between nut dietary and blood pressure.
Forty-three hypertension cases and 53 controls serum samples were obtained for lipidomic data analysis using a liquid chromatography mass spectrometry platform.
We identified four lipid metabolites that are associated with nut intake by a generalized linear model and logistic regression analysis, including phosphatidylglycerol 43:6 [PG (43:6)], phosphatidylcholine 18:0/20:3 [PC (18:0/20:3)], and two phosphatidylethanolamine (PE) compounds [PE (P-16:0/20:4) and PE (P-22:0/18:2)]. Logistic regression analysis indicated that the levels of PG (43:6) and PE (P-16:0/20:4) were negatively associated with hypertension in children, which might be useful biomarkers for predicting childhood hypertension. Further mediation analysis revealed that PG (43:6) and PC (18:0/20:3) function as mediating variables between nut intake and blood pressure levels.
This study provides scientific evidence that nut consumption induces some beneficial changes in lipid metabolism, which may reduce the risk of hypertension in children.
尽管坚果在预防心血管疾病方面发挥着重要作用，但坚果调节血压的代谢线索尚未被充分理解。
我们在中国西南部儿童前瞻性队列研究中进行了一项嵌套病例对照研究，以探讨与坚果饮食和血压相关的潜在脂质代谢物。
采用液相色谱-质谱联用平台对 43 例高血压病例和 53 例对照血清样本进行脂质组学数据分析。
我们通过广义线性模型和逻辑回归分析确定了与坚果摄入相关的四种脂质代谢物，包括磷脂酰甘油 43:6[PG（43:6）]、磷脂酰胆碱 18:0/20:3[PC（18:0/20:3）]和两种磷脂酰乙醇胺（PE）化合物[PE（P-16:0/20:4）和 PE（P-22:0/18:2）]。逻辑回归分析表明，PG（43:6）和 PE（P-16:0/20:4）水平与儿童高血压呈负相关，这可能是预测儿童高血压的有用生物标志物。进一步的中介分析表明，PG（43:6）和 PC（18:0/20:3）作为坚果摄入与血压水平之间的中介变量发挥作用。
本研究提供了科学证据，表明坚果摄入可引起脂质代谢的有益变化，从而降低儿童患高血压的风险。
