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眼睑和阴道粘连作为中毒性表皮坏死松解症的严重后遗症

Eyelid and Vaginal Adhesions as Severe Sequelae of Toxic Epidermal Necrolysis.

作者信息

Suzuki Kaori, Watanabe Yuko, Imai Yuichi, Yamaguchi Yukie

机构信息

Department of Environmental-Immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, JPN.

Department of Obesterics and Gynecology, Yokohama City University Graduate School of Medicine, Yokohama, JPN.

出版信息

Cureus. 2023 Jul 7;15(7):e41496. doi: 10.7759/cureus.41496. eCollection 2023 Jul.

DOI:10.7759/cureus.41496
PMID:37551206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10404347/
Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are mucocutaneous diseases featured by severe sequelae and high mortality rates. In addition to ocular involvement, gynecological involvement is often observed in patients with TEN with possible occurrence of partial or complete adhesions of the labia majora, labia minora, and vaginal walls as severe sequelae. Although the gynecological sequelae of TEN severely affect patients' quality of life, there is a lack of awareness among medical professionals. Moreover, preventive measures and the effectiveness of treatment have not yet been fully verified. Herein, we describe a case of TEN with severe sequelae of eyelid and vaginal adhesions.

摘要

史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是具有严重后遗症和高死亡率的皮肤黏膜疾病。除眼部受累外，TEN患者常出现妇科受累，严重后遗症可能包括大阴唇、小阴唇和阴道壁部分或完全粘连。尽管TEN的妇科后遗症严重影响患者的生活质量，但医学专业人员对此认识不足。此外，预防措施和治疗效果尚未得到充分验证。在此，我们报告一例伴有眼睑和阴道粘连严重后遗症的TEN病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/f89d1042a674/cureus-0015-00000041496-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/e24c66c87733/cureus-0015-00000041496-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/48627a15f8b1/cureus-0015-00000041496-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/f5b6c050227e/cureus-0015-00000041496-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/b9ddedf17274/cureus-0015-00000041496-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/5624b2fb8cad/cureus-0015-00000041496-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/f89d1042a674/cureus-0015-00000041496-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/e24c66c87733/cureus-0015-00000041496-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/48627a15f8b1/cureus-0015-00000041496-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/f5b6c050227e/cureus-0015-00000041496-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/b9ddedf17274/cureus-0015-00000041496-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/5624b2fb8cad/cureus-0015-00000041496-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1be/10404347/f89d1042a674/cureus-0015-00000041496-i06.jpg

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本文引用的文献

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泰国 HLA-B*44:03-HLA-C*07:01 单倍型与感冒药相关的史蒂文斯-约翰逊综合征伴严重眼部并发症的相关性。
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