Cherruault Y, Prost J F, Karpouzas I, Hotchen M
Int J Biomed Comput. 1986 May;18(3-4):283-300. doi: 10.1016/0020-7101(86)90024-3.
In this paper we propose a non-linear model for explaining the relation between doses, blood levels and pharmacodynamic effects. Several models are examined and a functional relation (without derivatives or integrals) is retained. From there the medical system is optimized by using optimal control methods. In practice, optimal doses and times are numerically determined for the drug tertatolol.
在本文中，我们提出了一个非线性模型来解释剂量、血药浓度和药效之间的关系。我们研究了几种模型，并保留了一个函数关系（无导数或积分）。在此基础上，利用最优控制方法对医疗系统进行优化。在实际应用中，通过数值计算确定了药物特他洛尔的最佳剂量和用药时间。
