镰状细胞贫血患者甲状腺的超声剪切波弹性成像

Ultrasonographic shear wave elastography of the thyroid in patients with sickle cell anemia.

作者信息

Burakgazi Gulen, Ilhan Gul, Ozcan Oguzhan, Dirican Emre

机构信息

Department of Radiology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay 31100, Turkey.

Department of Hematology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay 31100, Turkey.

出版信息

Asian Biomed (Res Rev News). 2022 Jun 30;16(3):137-143. doi: 10.2478/abm-2022-0017. eCollection 2022 Jun.

DOI:10.2478/abm-2022-0017

PMID:37551381

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10321170/

Abstract

BACKGROUND

Although thyroid radiology has been conducted in patients with sickle cell anemia (SCA), to our knowledge, there is no report of thyroid gland assessment using ultrasonographic shear wave elastography (US-SWE).

OBJECTIVES

To determine values for ultrasonographic US-SWE of the thyroid in patients with SCA and correlations between thyroid elasticity and biochemical variables used to evaluate thyroid function.

METHODS

Prospective case-control observational study of 36 patients with SCA and 33 healthy volunteer controls. US-SWE measurements of thyroid gland parenchyma and biochemical parameters of the participants were obtained and compared, and the diagnostic accuracy of elasticity was determined.

RESULTS

The thyroid volume was smaller in patients with SCA than that in controls ( = 0.001). Compared with the controls, the patients with SCA had significantly lower serum levels of free triiodothyronine (fT3) ( = 0.004) and thyroglobulin (Tg) ( = 0.001) and significantly higher levels of thyroid-stimulating hormone ( = 0.028). Thyroid stiffness was significantly higher in the left lobe (LL) of the patients with SCA than in the controls ( = 0.003). In the patients with SCA, we found a significant correlation between right lobe (RL) and LL stiffness and serum levels of Tg (RL [ = -0.439] and LL [ = -0.484]; = 0.021) and fT3 (RL [ = -0.463] and LL [ = -0.386]; = 0.012). Receiver operating characteristic (ROC) curve analysis of thyroid elasticity that represented a diagnosis of SCA found a cutoff of >7.31 kPa, a sensitivity of 52.0%, and a specificity of 72.0% for the RL ( = 0.316, area under the curve [AUC] 0.570), and a cutoff of >8.06 kPa, a sensitivity of 58.0%, and a specificity of 84.0% for the LL ( = 0.011, AUC 0.680).

CONCLUSIONS

US-SWE can be used to follow up thyroid changes in patients with SCA.

摘要

背景

尽管已对镰状细胞贫血（SCA）患者进行了甲状腺放射学检查，但据我们所知，尚无关于使用超声剪切波弹性成像（US-SWE）评估甲状腺的报告。

目的

确定SCA患者甲状腺超声US-SWE的值，以及甲状腺弹性与用于评估甲状腺功能的生化变量之间的相关性。

方法

对36例SCA患者和33名健康志愿者对照进行前瞻性病例对照观察研究。获取并比较参与者甲状腺实质的US-SWE测量值和生化参数，并确定弹性的诊断准确性。

结果

SCA患者的甲状腺体积小于对照组（P = 0.001）。与对照组相比，SCA患者的血清游离三碘甲状腺原氨酸（fT3）水平（P = 0.004）和甲状腺球蛋白（Tg）水平（P = 0.001）显著降低，促甲状腺激素水平显著升高（P = 0.028）。SCA患者左叶（LL）的甲状腺硬度显著高于对照组（P = 0.003）。在SCA患者中，我们发现右叶（RL）和LL硬度与血清Tg水平（RL [P = -0.439]和LL [P = -0.484]；P = 0.021）以及fT3水平（RL [P = -0.463]和LL [P = -0.386]；P = 0.012）之间存在显著相关性。代表SCA诊断的甲状腺弹性的受试者操作特征（ROC）曲线分析发现，RL的临界值>7.31 kPa，灵敏度为52.0%，特异性为72.0%（P = 0.316，曲线下面积[AUC] 0.570），LL的临界值>8.06 kPa，灵敏度为58.0%，特异性为84.0%（P = 0.011，AUC 0.680）。