土耳其新冠肺炎住院患者的神经学表现及病因危险因素
Neurological manifestations and etiological risk factors in patients hospitalized with COVID-19 in Turkey.
作者信息
Usta Nuray Can, Kartal Seyfi, Gunay Betul Onal, Boz Cavit
机构信息
Department of Neurology, University of Health Science, Trabzon Kanuni Training and Research Hospital, Trabzon 61250, Turkey.
Department of Anaesthesiology and Reanimation, University of Health Science, Trabzon Kanuni Training and Research Hospital, Trabzon 61250, Turkey.
出版信息
Asian Biomed (Res Rev News). 2022 Feb 28;16(1):23-30. doi: 10.2478/abm-2022-0004. eCollection 2022 Feb.
BACKGROUND
Coronavirus disease 2019 (COVID-19) can affect the neurological as well as the respiratory system. Neurological manifestations may involve the central or peripheral nervous systems, or musculoskeletal system. Findings can range from mild presentations, such as headache and anosmia, to severe complications, such as stroke and seizure.
OBJECTIVES
To evaluate the neurological findings and to determine etiological risk factors for mortality in patients hospitalized for COVID-19.
METHODS
Medical records of patients with COVID-19 who were hospitalized and sought neurological consultation between March 2020 and March 2021 at a reference pandemic hospital in Turkey were reviewed retrospectively in a cross-sectional study design.
RESULT
We included data from 150 (94 male) patients. Their mean age ± standard deviation was 68.56 ± 16.02 (range 21-97) years. The patients were categorized into 2 groups according to any acute neurological event or progression of neurological disease. Ischemic cerebrovascular events, seizures, and encephalopathy were the most common acute neurological events, while deterioration in consciousness, epileptic seizures, and Parkinson disease were observed in those with progression of neurological disease. Abnormal neurological findings were found at a mean of 7.8 ± 9.7 days following COVID-19 diagnosis and 50 (a third of) patients died. A logistic regression model found that advanced age, increased Modified Charlson Comorbidity Index (MCCI) score, and prolonged duration of hospitalization were factors significantly associated with increased mortality; however, sex and day of abnormal neurological findings after COVID-19 diagnosis were not. Common conditions accompanying neurological events were hypertension, coronary artery disease-heart failure, and diabetes mellitus.
CONCLUSION
COVID-19 may present with neurological symptoms in our Turkish patients and comorbidities are often present.
背景
2019冠状病毒病（COVID-19）可影响神经系统以及呼吸系统。神经表现可能涉及中枢或周围神经系统，或肌肉骨骼系统。其表现范围从轻微症状，如头痛和嗅觉丧失，到严重并发症，如中风和癫痫发作。
目的
评估COVID-19住院患者的神经学表现，并确定其死亡的病因风险因素。
方法
在一项横断面研究设计中，对2020年3月至2021年3月期间在土耳其一家参考大流行医院住院并寻求神经科会诊的COVID-19患者的病历进行回顾性分析。
结果
我们纳入了150名（94名男性）患者的数据。他们的平均年龄±标准差为68.56±16.02（范围21 - 97）岁。根据任何急性神经事件或神经疾病进展，将患者分为2组。缺血性脑血管事件、癫痫发作和脑病是最常见的急性神经事件，而在神经疾病进展的患者中观察到意识恶化、癫痫发作和帕金森病。在COVID-19诊断后平均7.8±9.7天发现神经学异常表现，50名（三分之一）患者死亡。逻辑回归模型发现，高龄、改良查尔森合并症指数（MCCI）评分增加和住院时间延长是与死亡率增加显著相关的因素；然而，性别和COVID-19诊断后出现神经学异常表现的天数则不然。伴随神经事件的常见疾病有高血压、冠状动脉疾病 - 心力衰竭和糖尿病。
结论
在我们的土耳其患者中，COVID-19可能伴有神经症状，且常伴有合并症。
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