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新冠病毒(COVID-19)免疫力与疫苗:药剂师需要了解的内容。

COVID-19 immunity and vaccines: what a pharmacist needs to know.

作者信息

Darwish Rula M

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Aljubeiha, Amman 00962, Jordan.

出版信息

Asian Biomed (Res Rev News). 2021 Apr 30;15(2):51-67. doi: 10.2478/abm-2021-0008. eCollection 2021 Apr.

Abstract

COVID-19 vaccines are being produced using different platforms by different companies, some of which are entering Phase 3 and 4 trials. Due to the pandemic, this production has been accelerated, which leaves a window for speculation on the method of production and safety. Pharmacists are familiar with vaccination; however, COVID-19 vaccines are still new and further work is needed to clarify many aspects, including side effects, methods of storage, and number of doses. Prioritization of vaccination has been implemented to a certain extent, but no clear strategy is available. A comprehensive overview on immunity and immunological principles for the design of COVID-19 vaccine strategies is provided in this narrative review and the current COVID-19 vaccine landscape is discussed, in addition to exploring the principles for prioritization of vaccination using data from articles available in PubMed and from health organizations. Pharmacists should have a better understanding of COVID-19 vaccines and their manufacture. This would also allow better counseling of the public on COVID 19, immunization, and explaining prioritization basis and vaccination programs.

摘要

不同公司正在使用不同平台生产新冠疫苗,其中一些已进入3期和4期试验。由于疫情,疫苗生产加速,这为对生产方法和安全性的猜测留下了空间。药剂师熟悉疫苗接种;然而,新冠疫苗仍然是新事物,还需要进一步开展工作以阐明诸多方面,包括副作用、储存方法和剂量数量。疫苗接种的优先级在一定程度上已经实施,但尚无明确策略。本叙述性综述提供了关于新冠疫苗策略设计的免疫和免疫学原理的全面概述,并讨论了当前的新冠疫苗格局,此外还利用来自PubMed上的文章和卫生组织的数据探讨了疫苗接种优先级的原则。药剂师应更好地了解新冠疫苗及其生产。这也将使药剂师能够更好地为公众提供关于新冠病毒、免疫接种的咨询,并解释优先级依据和疫苗接种计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/456a/10388771/b6fa2735c4dd/j_abm-2021-0008_fig_001.jpg

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