Chen Wanzi, Yang Jinghui, Chen Ping
Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
Asian Biomed (Res Rev News). 2021 Apr 30;15(2):79-89. doi: 10.2478/abm-2021-0010. eCollection 2021 Apr.
Patients diagnosed with acute myeloid leukemia (AML) in childhood have a poor prognosis. A better understanding of prognostic factors will assist patients and clinicians in making difficult treatment decisions.
To understand further the cytogenetic characteristics of and reassess the prognostic value of cytogenetic abnormalities in childhood AML.
Conventional karyotypes of 107 children with AML were analyzed retrospectively. The cases were divided into 4 groups based on genetic rearrangements; namely patients with: t(15;17)/; t(8;21)/ or inv(16)(p13;q22) and t(16;16)/; -7 or complex karyotypes; normal karyotypes or other cytogenetic changes. Differences in age, sex, leukocyte count, event-free survival (EFS), and overall survival (OS) were analyzed.
All French-American-British (FAB) subtypes of AML were detected in 107 patients. We successfully cultured 81 of 107 bone marrow specimens, of which 60 cases had abnormal karyotypes. The most common abnormal karyotypes were t(8;21) (17/81 cases), followed by t(15;17) (13/81 cases), -X/Y (10/81 cases). There were no significant differences ( > 0.05) in age, sex, or leukocyte counts between the 4 groups. The differences in 3-year EFS and OS between each pair were significant, except for groups of patients with t(8;21)/ and patients with normal karyotypes or other cytogenetic changes ( = 0.054).
Chromosomal abnormalities may provide important prognostic factors for AML in children and be helpful for risk stratification and individual treatment.
儿童急性髓系白血病（AML）患者预后较差。更好地了解预后因素将有助于患者和临床医生做出艰难的治疗决策。
进一步了解儿童AML的细胞遗传学特征，并重新评估细胞遗传学异常的预后价值。
回顾性分析107例儿童AML患者的常规核型。根据基因重排将病例分为4组；即：t(15;17)/；t(8;21)/或inv(16)(p13;q22)和t(16;16)/；-7或复杂核型；正常核型或其他细胞遗传学改变。分析年龄、性别、白细胞计数、无事件生存期（EFS）和总生存期（OS）的差异。
107例患者中检测到了所有法美英（FAB）亚型的AML。107份骨髓标本中有81份成功培养，其中60例核型异常。最常见的异常核型是t(8;21)（17/81例），其次是t(15;17)（13/81例），-X/Y（10/81例）。4组之间在年龄、性别或白细胞计数方面无显著差异（>0.05）。除t(8;21)/组与正常核型或其他细胞遗传学改变组外，各配对组之间的3年EFS和OS差异均有统计学意义（=0.054）。
染色体异常可能为儿童AML提供重要的预后因素，有助于风险分层和个体化治疗。
