Zhu Ping-Ping, Wen Rui-Ting, Yang Zhi-Gang
Department of Hematology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang 524045, Guangdong Province, China.
Department of Hematology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang 524045, Guangdong Province, China.E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Aug;31(4):1229-1232. doi: 10.19746/j.cnki.issn.1009-2137.2023.04.046.
The homing and engraftment of hematopoietic stem cells (HSC) into bone marrow is the first critical step for successful clinical hematopoietic stem cell transplantation (HSCT). SDF-1 / CXCR4 is considered to be a very promising target to promote HSC homing. In recent years, with the in-depth research on the HSC homing, a variety of new strategies for promoting HSC homing and engraftment have been explored, such as nuclear hormone receptor, histone deacetylase inhibitor, prostaglandin and metabolic regulation, so as to increase the success rate of HSCT and improve the survival of patients. In this review, the recent research advances in the mechanism of HSC homing and strategies to promote HSC homing and engraftment were summarized and discussed.
造血干细胞（HSC）归巢并植入骨髓是成功进行临床造血干细胞移植（HSCT）的首个关键步骤。基质细胞衍生因子-1（SDF-1）/ CXC趋化因子受体4（CXCR4）被认为是促进造血干细胞归巢的一个非常有前景的靶点。近年来，随着对造血干细胞归巢研究的深入，已探索出多种促进造血干细胞归巢和植入的新策略，如核激素受体、组蛋白去乙酰化酶抑制剂、前列腺素及代谢调节等，以提高造血干细胞移植的成功率并改善患者生存率。在本综述中，总结并讨论了造血干细胞归巢机制以及促进造血干细胞归巢和植入策略的最新研究进展。
