Ling Xiao-Sui, He Hai-Ping, Zhang Li-Hua, Li Fan
The Affiliated Hospital of Kunming University of Science and Technology; Department of Hematology, the First People's Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China.
The Affiliated Hospital of Kunming University of Science and Technology; Department of Hematology, the First People's Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2023 Aug;31(4):1233-1236. doi: 10.19746/j.cnki.issn.1009-2137.2023.04.047.
Multiple myeloma (MM) is a malignant proliferative disease of plasma cells. Bone marrow mesenchymal stem cells (MSC) play an important role in the progression of MM. Compared with normal donor derived MSC (ND-MSC), MM patients derived MSC (MM-MSC) exhibit abnormalities in genes, signaling pathways, protein expression levels and cytokines secreted by themselves. Moreover, the exosomes of MM-MSC can interact with the bone marrow microenvironment. The above reasons can lead to MM cell proliferation, chemoresistance, impaired osteogenic differentiation of MM-MSC, and affect the immunomodulatory capacity of MM patients. In order to further understand the pathogenesis and related influencing factors of MM, this paper reviews the latest research progress of MM-MSC.
多发性骨髓瘤（MM）是一种浆细胞恶性增殖性疾病。骨髓间充质干细胞（MSC）在MM的进展中起重要作用。与正常供体来源的MSC（ND-MSC）相比，MM患者来源的MSC（MM-MSC）在基因、信号通路、蛋白质表达水平及自身分泌的细胞因子方面均表现出异常。此外，MM-MSC的外泌体可与骨髓微环境相互作用。上述原因可导致MM细胞增殖、化疗耐药、MM-MSC成骨分化受损，并影响MM患者的免疫调节能力。为进一步了解MM的发病机制及相关影响因素，本文综述了MM-MSC的最新研究进展。
