Guirat Dhouib Naouel, Lachtar Fatma, Ben Abdallah Fethi, Dahech Dhia, Guirat Rim, Ghozzi Hanène, Bahloul Najla, Ben Mahmoud Lobna, Sahnoun Zouheir, Zeghal Khaled
Tunis Med. 2022;100(12):877-880.
The term multiple drug intolerance syndrome is used for patients who express adverse drug reactions to three or more drugs without a known immunological mechanism. It is a distinct clinical entity, different from cross-reactivity. The symptoms can range from a benign rash to life threatening syndromes like drug reaction with eosinophilia and systemic symptoms.
We report the case of an 8-year-old child with primary ciliary dyskinesia complicated by bronchiectasis who presented multiple drug intolerance syndrome.Through this observation; we discuss the diagnostic elements of this syndrome.
In the absence of validated criteria for diagnosing multiple drug intolerance syndrome, a detailed history is essential, especially to identify the warning signs and the risk factors.
“多种药物不耐受综合征”这一术语用于那些对三种或更多药物表现出不良药物反应且无已知免疫机制的患者。它是一种独特的临床实体，不同于交叉反应。症状范围从良性皮疹到危及生命的综合征，如伴有嗜酸性粒细胞增多和全身症状的药物反应。
我们报告一例8岁原发性纤毛运动障碍合并支气管扩张的儿童出现多种药物不耐受综合征的病例。通过该病例观察，我们讨论了该综合征的诊断要点。
在缺乏诊断多种药物不耐受综合征的有效标准的情况下，详细的病史至关重要，尤其是要识别警示信号和风险因素。
