Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, 6725, Hungary.
CNS Oncol. 2023 Dec 1;12(4):CNS103. doi: 10.2217/cns-2023-0006. Epub 2023 Aug 8.
Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics.
罗-道氏病（RDD）是一种罕见的 S100 阳性组织细胞增生症，可引起结内和结外疾病。我们报告一例 53 岁男性患者。磁共振成像描述了一种斑块样脑膜病变，术前诊断为脑膜瘤。组织学上，可见淋巴细胞、浆细胞和组织细胞密集浸润，此外，标本中存在明显的胞饮现象。在组织细胞中观察到 S100 蛋白核和细胞质阳性，以及 Cyclin D1 核阳性。该病例被诊断为 RDD。颅内 RDD 的形态学表现与影像学检查可能会带来鉴别诊断的挑战。正确的诊断基于存在具有胞饮现象的组织细胞，以及适当定义的免疫组织化学特征。
