Majumdar Kaushik, Saran Ravindra K, Chaurasia Pramod K, Tyagi Ila, Singh Daljit
Department of Pathology, G B Pant Hospital, Jawahalal Nehru Marg, New Delhi, India.
Clin Neuropathol. 2013 Mar-Apr;32(2):122-7. doi: 10.5414/NP300517.
In lymphoplasmacyte-rich meningioma (LRM) meningothelial whorls are overshadowed by exuberant infiltration by lymphocytes, plasma cells and few histiocytes. Hence, lesions with lymphoplasmacytic proliferation form the histological differentials. We describe the, to the best of our knowledge, first case of LRM with occasiona emperipolesis, creating a diagnostic dilemma with Rosai-Dorfman disease (RDD), around the region of sphenoid wing. LRM was favored due to the presence of epithelial membrane antigen (EMA) and vimentin positive meningothelial whorls, forming approximately 10% of the tumor tissue. Documentation of such cases may help to understand the importance of inflammatory cells and meningothelial whorls, as a manifestation of host response at the leptomeninges.
在富于淋巴细胞和浆细胞的脑膜瘤（LRM）中，脑膜上皮性漩涡被淋巴细胞、浆细胞及少量组织细胞的大量浸润所掩盖。因此，伴有淋巴浆细胞增殖的病变构成了组织学鉴别诊断。据我们所知，我们描述了首例发生于蝶骨嵴区域的伴有偶见血细胞吞噬现象的LRM，这与Rosai-Dorfman病（RDD）形成了诊断难题。由于存在上皮膜抗原（EMA）和波形蛋白阳性的脑膜上皮性漩涡，且其构成肿瘤组织的约10%，故倾向于诊断为LRM。记录此类病例可能有助于理解炎症细胞和脑膜上皮性漩涡作为软脑膜宿主反应表现的重要性。
