Florida State University, Department of Nutrition and Integrative Physiology, Tallahassee, FL, USA.
Florida State University, Institute of Sports Sciences and Medicine, Tallahassee, FL, USA.
J Int Soc Sports Nutr. 2023 Dec;20(1):2243252. doi: 10.1080/15502783.2023.2243252.
Chronic pain affects 19% of adults in the United States, with increasing prevalence in active and aging populations. Pain can limit physical activity and activities of daily living (ADLs), resulting in declined mental and social health. Nutritional interventions for pain currently target inflammation or joint health, but few influence both. Collagen, the most abundant protein in the human body and constituent of the extra cellular matrix, is such a nutraceutical. While there have been reports of reductions in pain with short-term collagen peptide (CP) supplementation, there are no long-term studies specifically in healthy middle-aged active adults.
To determine the effects of daily CP consumption over 3, 6, and 9 months on survey measures of pain, function, and physical and mental health using The Knee Injury & Osteoarthritis Outcomes Score (KOOS) and Veterans Rand 12 (VR-12) in middle-aged active adults.
This study was a double-blind randomized control trial with three treatment groups (Placebo, 10 g/d CP, and 20 g/d CP).
Improvements in ADLs ( = .031, η = .096) and pain ( = .037, η = .164) were observed with 10 g/d CP over 6 months, although pain only improved in high frequency exercisers (>180 min/week). Additionally, VR-12 mental component scores (MCS) improved with 10 g/d of CP over 3-9 months ( = .017, η = .309), while physical component scores (PCS) improved with 20 g/d of CP over 3-9 months, but only in females ( = .013, η= .582).
These findings suggest 10 to 20 g/d of CP supplementation over 6 to 9 months may improve ADLs, pain, MCS, and PCS in middle-aged active adults.
慢性疼痛影响美国 19%的成年人，在活跃人群和老龄化人群中的患病率不断增加。疼痛会限制身体活动和日常生活活动（ADL），导致心理健康和社会健康状况下降。目前，针对疼痛的营养干预措施针对炎症或关节健康，但很少同时影响两者。胶原蛋白是人体中最丰富的蛋白质，也是细胞外基质的组成部分，是一种营养保健品。虽然有短期补充胶原蛋白肽（CP）可减轻疼痛的报告，但在健康的中年活跃成年人中，尚无长期研究。
确定每天摄入 CP 超过 3、6 和 9 个月对中年活跃成年人的疼痛、功能以及身体和心理健康的调查测量的影响，使用膝关节损伤和骨关节炎结局评分（KOOS）和退伍军人兰德 12 分（VR-12）。
这是一项双盲随机对照试验，有三个治疗组（安慰剂、10g/d CP 和 20g/d CP）。
在 6 个月时，10g/d CP 可改善 ADL（ = .031，η = .096）和疼痛（ = .037，η = .164），但只有高频率运动者（>180 分钟/周）的疼痛才有所改善。此外，10g/d CP 可在 3-9 个月内改善 VR-12 心理成分评分（MCS）（ = .017，η = .309），而 20g/d CP 可在 3-9 个月内改善物理成分评分（PCS），但仅在女性中（ = .013，η=.582）。
这些发现表明，在 6 至 9 个月内补充 10 至 20g/d CP 可能会改善中年活跃成年人的 ADL、疼痛、MCS 和 PCS。
