HLA-B*53:01 是导致非裔美国人苯妥英和其他抗癫痫药物肝损伤的重要危险因素。
HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans.
机构信息
Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Duke University School of Medicine, Durham, North Carolina, USA.
出版信息
Am J Gastroenterol. 2024 Jan 1;119(1):200-202. doi: 10.14309/ajg.0000000000002454. Epub 2023 Aug 8.
Abstract
INTRODUCTION
To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA).
METHODS
In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs, and 5816 AA population controls were included.
RESULTS
HLA-B53:01 was significantly associated with aromatic AED-DILI (odds ratio: 4.52, 95% confidence interval: 2.42-8.44, P = 1.46 × 10 -5 ). Phenytoin DILI showed the strongest association with HLA-B53:01 (odds ratio: 9.17; 95% confidence interval: 3.61-23.28, P = 1.1 × 10 -5 ). The HLA-B*53:01 allele was carried by 8 of 9 AA phenytoin DILI cases.
DISCUSSION
HLA-B*53:01 is a significant risk factor of liver injury due to antiepileptics, particularly phenytoin, in AA.
摘要
简介
本研究旨在探究与非裔美国人（AA）抗癫痫药（AED）相关肝损伤（DILI）相关的人类白细胞抗原（HLA）等位基因。
方法
本研究纳入了 21 例 AED 药物诱导性肝损伤（DILI）的 AA、176 例非 AED 药物所致 DILI 的 AA 以及 5816 例 AA 人群对照。
结果
HLA-B53:01 与芳香族 AED-DILI 显著相关（比值比：4.52，95%置信区间：2.42-8.44，P = 1.46 × 10-5）。苯妥英钠 DILI 与 HLA-B53:01 关联最强（比值比：9.17；95%置信区间：3.61-23.28，P = 1.1 × 10-5）。9 例苯妥英钠 DILI 患者中有 8 例携带 HLA-B*53:01 等位基因。
讨论
HLA-B*53:01 是 AA 中抗癫痫药，特别是苯妥英钠导致肝损伤的显著危险因素。
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