针对毒蕈碱受体对多巴胺系统的作用：治疗神经精神疾病的新策略。
Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders.
机构信息
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Department of Cellular and Molecular Physiology, Interdepartmental Neuroscience Program, and Wu Tsai Institute, Yale University, New Haven, Connecticut, USA.
出版信息
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:277-289. doi: 10.1146/annurev-pharmtox-051921-023858. Epub 2023 Aug 9.
Abstract
Cholinergic regulation of dopamine (DA) signaling has significant implications for numerous disorders, including schizophrenia, substance use disorders, and mood-related disorders. The activity of midbrain DA neurons and DA release patterns in terminal regions are tightly regulated by cholinergic neurons found in both the striatum and the hindbrain. These cholinergic neurons can modulate DA circuitry by activating numerous receptors, including muscarinic acetylcholine receptor (mAChR) subtypes. This review specifically focuses on the complex role of M2, M4, and M5 mAChR subtypes in regulating DA neuron activity and DA release and the potential clinical implications of targeting these mAChR subtypes.
摘要
胆碱能调节多巴胺（DA）信号对许多疾病具有重要意义，包括精神分裂症、物质使用障碍和与情绪相关的障碍。中脑 DA 神经元的活性和终端区域的 DA 释放模式受到纹状体和后脑中发现的胆碱能神经元的紧密调节。这些胆碱能神经元可以通过激活多种受体来调节 DA 回路，包括毒蕈碱乙酰胆碱受体（mAChR）亚型。本综述特别关注 M2、M4 和 M5 mAChR 亚型在调节 DA 神经元活性和 DA 释放中的复杂作用，以及靶向这些 mAChR 亚型的潜在临床意义。
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