棘白菌素类药物联合特比萘芬治疗外瓶霉引起的暗色丝孢霉病：一例病例报告及文献复习。

Combination therapy with itraconazole and terbinafine for phaeohyphomycosis caused by Exophiala spinifera: A case report and literature review.

机构信息

Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Department of Dermatology and Venereology, The Second Affiliated Hospital of Guangzhou Medical University.

出版信息

Mycoses. 2023 Nov;66(11):1012-1017. doi: 10.1111/myc.13642. Epub 2023 Aug 8.

DOI:10.1111/myc.13642

PMID:37553547

Abstract

Exophiala spinifera is a rare dematiaceous fungus causing cutaneous, subcutaneous and disseminated phaeohyphomycosis (PHM). Standard antifungal therapy for PHM is still uncertain. Here, we report a case of a Chinese male with PHM caused by E. spinifera, who received significant clinical improvement after the treatment with oral itraconazole and terbinafine. With the aim of evaluating the antifungal therapy for PHM caused by E. spinifera, a detailed review was performed.

摘要

棘状外瓶霉是一种罕见的暗色真菌，可引起皮肤、皮下和播散性暗色丝孢霉病（PHM）。目前，PHM 的标准抗真菌治疗仍不确定。本研究报告了一例中国男性 PHM 病例，由棘状外瓶霉引起，经伊曲康唑和特比萘芬口服治疗后临床显著改善。为了评估棘状外瓶霉引起的 PHM 的抗真菌治疗，我们进行了详细的文献回顾。