维拉帕米类似物阿尼帕米和罗尼帕米对清醒大鼠缺血性心律失常的作用。
Actions of the verapamil analogues, anipamil and ronipamil, against ischaemia-induced arrhythmias in conscious rats.
作者信息
Curtis M J, Walker M J, Yuswack T
出版信息
Br J Pharmacol. 1986 Jun;88(2):355-61. doi: 10.1111/j.1476-5381.1986.tb10211.x.
Abstract
Two analogues of verapamil, ronipamil and anipamil, were tested for their ability to reduce arrhythmias induced by occlusion of the left anterior descending coronary artery in conscious rats. Only anipamil (50 and 150 mg kg-1 orally) produced a statistically significant reduction in arrhythmias; it was most effective against ventricular fibrillation. Ronipamil at the same doses had limited antiarrhythmic actions. Only anipamil delayed the development of ECG signs of ischaemia, while both drugs reduced the magnitude of such changes. Anipamil has a more favourable ratio of antiarrhythmic to hypotensive effects when compared with verapamil.
摘要
对维拉帕米的两种类似物罗尼帕米和阿尼帕米进行了测试，以检验它们减少清醒大鼠左冠状动脉前降支闭塞诱发心律失常的能力。只有阿尼帕米（口服剂量为50和150毫克/千克）能使心律失常有统计学意义地显著减少；它对心室颤动最为有效。相同剂量的罗尼帕米抗心律失常作用有限。只有阿尼帕米延缓了缺血心电图征象的出现，而两种药物都减轻了此类变化的程度。与维拉帕米相比，阿尼帕米的抗心律失常与降压作用之比更有利。
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