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系统性分析人类癌症中的组蛋白乙酰化调控因子。

Systematic analysis of histone acetylation regulators across human cancers.

机构信息

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuhan, 430060, China.

Department of Hematology, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuhan, 430060, China.

出版信息

BMC Cancer. 2023 Aug 8;23(1):733. doi: 10.1186/s12885-023-11220-7.

DOI:10.1186/s12885-023-11220-7
PMID:37553641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10408135/
Abstract

BACKGROUND

Histone acetylation (HA) is an important and common epigenetic pathway, which could be hijacked by tumor cells during carcinogenesis and cancer progression. However, the important role of HA across human cancers remains elusive.

METHODS

In this study, we performed a comprehensive analysis at multiple levels, aiming to systematically describe the molecular characteristics and clinical relevance of HA regulators in more than 10000 tumor samples representing 33 cancer types.

RESULTS

We found a highly heterogeneous genetic alteration landscape of HA regulators across different human cancer types. CNV alteration may be one of the major mechanisms leading to the expression perturbations in HA regulators. Furthermore, expression perturbations of HA regulators correlated with the activity of multiple hallmark oncogenic pathways. HA regulators were found to be potentially useful for the prognostic stratification of kidney renal clear cell carcinoma (KIRC). Additionally, we identified HDAC3 as a potential oncogene in lung adenocarcinoma (LUAD).

CONCLUSION

Overall, our results highlights the importance of HA regulators in cancer development, which may contribute to the development of clinical strategies for cancer treatment.

摘要

背景

组蛋白乙酰化（HA）是一种重要且常见的表观遗传途径，在致癌和癌症进展过程中，肿瘤细胞可能会劫持该途径。然而，HA 在人类癌症中的重要作用仍难以捉摸。

方法

在这项研究中，我们在多个层面进行了全面分析，旨在系统描述超过 10000 个肿瘤样本中 33 种癌症类型的 HA 调节剂的分子特征和临床相关性。

结果

我们发现不同人类癌症类型的 HA 调节剂具有高度异质性的遗传改变景观。CNV 改变可能是导致 HA 调节剂表达失调的主要机制之一。此外，HA 调节剂的表达失调与多种标志性致癌途径的活性相关。HA 调节剂被发现可能有助于肾透明细胞癌（KIRC）的预后分层。此外，我们还鉴定出 HDAC3 可能是肺腺癌（LUAD）中的一个潜在癌基因。

结论

总体而言，我们的研究结果强调了 HA 调节剂在癌症发展中的重要性，这可能有助于制定癌症治疗的临床策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/26de85dbedbb/12885_2023_11220_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/1eb5b7d2a4a5/12885_2023_11220_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/d93b4878bcbd/12885_2023_11220_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/476e5d13654e/12885_2023_11220_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/6ed9cf483de1/12885_2023_11220_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/4df2e41c392d/12885_2023_11220_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/26de85dbedbb/12885_2023_11220_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/1eb5b7d2a4a5/12885_2023_11220_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/d93b4878bcbd/12885_2023_11220_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/476e5d13654e/12885_2023_11220_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/6ed9cf483de1/12885_2023_11220_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/4df2e41c392d/12885_2023_11220_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2314/10408135/26de85dbedbb/12885_2023_11220_Fig5_HTML.jpg

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