Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Department of Neurology, Ulm University Hospital, Ulm, Germany.
Ann Clin Transl Neurol. 2023 Oct;10(10):1904-1909. doi: 10.1002/acn3.51873. Epub 2023 Aug 8.
Beta-synuclein is a promising cerebrospinal fluid and blood biomarker of synaptic damage. Here we analysed its accuracy in the discrimination between sporadic Creutzfeldt-Jakob disease (n = 150) and non-prion rapidly progressive dementias (n = 106). In cerebrospinal fluid, beta-synuclein performed better than protein 14-3-3 (AUC 0.95 vs. 0.89) and, to a lesser extent, than total tau (AUC 0.92). Further, the diagnostic value of plasma beta-synuclein (AUC 0.91) outperformed that of plasma tau (AUC 0.79) and neurofilament light chain protein (AUC 0.65) and was comparable to that of cerebrospinal fluid biomarkers. Beta-synuclein might represent the first highly accurate blood biomarker for the diagnosis of sporadic Creutzfeldt-Jakob disease.
β-突触核蛋白是一种有前途的突触损伤的脑脊液和血液生物标志物。在这里，我们分析了其在鉴别散发性克雅氏病（n=150）和非朊病毒快速进行性痴呆（n=106）中的准确性。在脑脊液中，β-突触核蛋白的表现优于蛋白 14-3-3（AUC 0.95 与 0.89），并且在一定程度上优于总tau（AUC 0.92）。此外，血浆β-突触核蛋白（AUC 0.91）的诊断价值优于血浆 tau（AUC 0.79）和神经丝轻链蛋白（AUC 0.65），与脑脊液生物标志物相当。β-突触核蛋白可能代表首个用于诊断散发性克雅氏病的高度准确的血液生物标志物。
