Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, China.
Department of Otolaryngology, Dongping County People's Hospital, Taian, China.
Am J Rhinol Allergy. 2023 Nov;37(6):751-757. doi: 10.1177/19458924231193156. Epub 2023 Aug 8.
Evidence has shown that glucocorticoid-induced transcript 1 (GLCCI1) single nucleotide polymorphism (SNP) rs37937 is associated with asthma.
The objective of this study was to investigate whether the GLCCI1 SNP rs37937 is a risk factor for allergic rhinitis (AR) in a Chinese Han population.
A total of 220 individuals including 109 AR patients and 111 healthy subjects were included. The genotyping of GLCCI1 rs37973 was performed by the SNaPshot method. The correlations of rs37973 polymorphism, AR risk, and clinical characteristics were further analyzed, as well as the treatment response to intranasal corticosteroids (INCS) in AR patients of different genotypes.
Three GLCCI1 rs37973 SNP genotypes were identified in both AR patients and healthy subjects. Significant association between rs37973 polymorphism and AR under allele model, dominant model, heterozygote model, and homozygote model were shown. The A allele frequency of SNP rs37973 in AR was significantly higher than that in controls. The serum total immunoglobulin E (IgE) in AR patients of AA genotype was significantly higher than in patients of GA and GG genotype, and the serum total IgE in GA genotype was significantly higher than in GG genotype. Interestingly, after 4 weeks of INCS treatment for AR patients, the improvement of the nasal itching score, sneezing score, runny nose score, total nasal symptom score, and visual analog scale score of the GG genotype were worse than the AA or GA genotype.
The GLCCI1 rs37937 polymorphism is associated with the risk of developing AR and the response to INCS treatment in the Chinese Han population.
有证据表明，糖皮质激素诱导转录物 1（GLCCI1）单核苷酸多态性（SNP）rs37937 与哮喘有关。
本研究旨在探讨 GLCCI1 SNP rs37937 是否是汉族人群变应性鼻炎（AR）的危险因素。
共纳入 220 例个体，包括 109 例 AR 患者和 111 例健康对照者。采用 SNaPshot 方法对 GLCCI1 rs37973 进行基因分型。进一步分析 rs37973 多态性与 AR 风险、临床特征的相关性，以及不同基因型 AR 患者对鼻内皮质类固醇（INCS）治疗的反应。
在 AR 患者和健康对照者中均鉴定出 GLCCI1 rs37973 三种 SNP 基因型。rs37973 多态性与 AR 在等位基因模型、显性模型、杂合子模型和纯合子模型中均存在显著相关性。AR 患者 SNP rs37973 的 A 等位基因频率明显高于对照组。AA 基因型 AR 患者的血清总免疫球蛋白 E（IgE）明显高于 GA 和 GG 基因型，GA 基因型的血清总 IgE 明显高于 GG 基因型。有趣的是，在 AR 患者接受 4 周 INCS 治疗后，GG 基因型患者的鼻痒评分、喷嚏评分、流涕评分、总鼻部症状评分和视觉模拟评分的改善明显差于 AA 或 GA 基因型。
GLCCI1 rs37937 多态性与汉族人群 AR 的发病风险及 INCS 治疗反应有关。
