肥胖和2型糖尿病儿童炎症标志物水平及其与脂肪组织分布的关系
The Level of Inflammatory Markers and Their Relationship with Fat Tissue Distribution in Children with Obesity and Type 2 Diabetes Mellitus.
作者信息
Akalın Ertürk Beyza, Gülbahar Özlem, Kaymak Şahap Seda, Deveci Bulut Tuba Saadet, Çetinkaya Semra, Savaş Erdeve Şenay
机构信息
Health Sciences University, Dr Sami Ulus Obstetrics, Gynecology and Pediatrics Education And Research Hospital, Children's Health and Disease Health Implementation and Research Center, Ankara, Turkey.
Gazi University Faculty of Medicine, Ankara, Turkey.
出版信息
Turk Arch Pediatr. 2023 Sep;58(5):485-493. doi: 10.5152/TurkArchPediatr.2023.22288.
OBJECTIVE
This study aimed to determine the changes in proinflammatory and anti-inflam- matory markers in children aged 10-18, who were not diagnosed with type 2 diabetes mel- litus, were obese/overweight, and children with type 2 diabetes mellitus. In addition, we aimed to investigate whether these markers were associated with clinical and laboratory parame- ters, subcutaneous adipose tissue, preperitoneal adipose tissue, visceral adipose tissue, and hepatosteatosis.
MATERIALS AND METHODS
Children between the ages of 10 and 18, obese/overweight, with type 2 diabetes mellitus, and with a normal body mass index were included. Fat tissue thick- ness was measured. Tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-18, and interferon-γ as proinflammatory markers and transforming growth factor-β and interleukin-10 levels as anti-inflammatory markers were studied.
RESULTS
Twenty-eight (31.8%) controls, 44 (50%) obese/overweight, and 16 (18.2%) patients with type 2 diabetes mellitus were included in our study. Age, sex, and puberty were similar between the groups. In the type 2 diabetes mellitus group, the subcutaneous fat tissue thick- ness was higher than that in the obese group, and the preperitoneal and visceral fat tissue thicknesses were similar to those in the obese group. Proinflammatory markers and interleu- kin-10 levels were similar in the obese/overweight, type 2 diabetes mellitus, and control groups. Transforming growth factor-β levels were significantly lower in the type 2 diabetes mellitus group than in the control group (P = .039). Transforming growth factor-β levels and other labo- ratory variables did not differ significantly in the type 2 diabetes mellitus group.
CONCLUSION
While there was no change in all markers in the obese/overweight group com- pared with the control group, proinflammatory markers in the type 2 diabetes mellitus group were similar to those in the obese/overweight and control groups, and transforming growth factor-β level, an anti-inflammatory marker, was lower in the type 2 diabetes mellitus group than in the control group.
目的
本研究旨在确定10 - 18岁未患2型糖尿病的肥胖/超重儿童以及2型糖尿病儿童体内促炎和抗炎标志物的变化。此外，我们旨在研究这些标志物是否与临床和实验室参数、皮下脂肪组织、腹膜前脂肪组织、内脏脂肪组织以及肝脂肪变性相关。
材料与方法
纳入10至18岁、肥胖/超重、患有2型糖尿病以及体重指数正常的儿童。测量脂肪组织厚度。研究促炎标志物肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、白细胞介素-18和干扰素-γ以及抗炎标志物转化生长因子-β和白细胞介素-10的水平。
结果
本研究纳入了28名（31.8%）对照组儿童、44名（50%）肥胖/超重儿童以及16名（18.2%）2型糖尿病患者。各组之间的年龄、性别和青春期情况相似。在2型糖尿病组中，皮下脂肪组织厚度高于肥胖组，腹膜前和内脏脂肪组织厚度与肥胖组相似。肥胖/超重组、2型糖尿病组和对照组中的促炎标志物及白细胞介素-10水平相似。2型糖尿病组的转化生长因子-β水平显著低于对照组（P = 0.039）。2型糖尿病组的转化生长因子-β水平与其他实验室变量无显著差异。
结论
与对照组相比，肥胖/超重组的所有标志物均无变化，2型糖尿病组的促炎标志物与肥胖/超重组和对照组相似，而作为抗炎标志物的转化生长因子-β水平在2型糖尿病组中低于对照组。
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