基于柔性背衬的负载雪松醇可溶解微针，促进头发生长。
Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth.
机构信息
School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
出版信息
Expert Opin Drug Deliv. 2023 Jul-Dec;20(9):1267-1276. doi: 10.1080/17425247.2023.2244413. Epub 2023 Aug 8.
OBJECTIVES
The dissolvable microneedles loaded with cedrol based on flexible backing were developed to deliver cedrol directly and continuously to the dermis, where the drug concentration in the hair follicle can be increased locally.
METHODS
The tip-layer matrix solution was prepared by mixing cedrol and polyvinylpyrrolidone K25 (PVP K25), and the pedestal matrix solution was prepared with aqueous hyaluronic acid. The cedrol-loaded dissolvable microneedles (cedrol-DMNs) were prepared under vacuum conditions. The mechanical properties, pig skin penetration efficiency, in vitro cutaneous permeation test, and the amount of drug in the skin and receptor chamber were evaluated. Pharmacodynamical studies were performed with C57BL/6 mice.
RESULTS
The mechanical properties of cedrol-DMNs were good. In vitro cutaneous permeation tests and pharmacodynamical studies demonstrated that cedrol-DMN could efficiently deliver the drug to the deep dermis and effectively promote hair growth.
CONCLUSIONS
The cedrol-DMNs offer a promising strategy for treating patients suffering from hair loss.
目的
研制基于柔性背衬的载丁香酚可溶解微针，以将丁香酚直接、持续递送至真皮，从而增加局部毛囊内的药物浓度。
方法
采用混合丁香酚和聚乙烯吡咯烷酮 K25（PVP K25）制备针尖层基质溶液，采用含透明质酸的水溶液制备针座层基质溶液。在真空条件下制备载丁香酚可溶解微针（cedrol-DMNs）。评价其机械性能、猪皮渗透效率、体外透皮试验、皮肤和接收室中的药物含量，并进行药效学研究。
结果
丁香酚-DMNs 的机械性能良好。体外透皮试验和药效学研究表明，丁香酚-DMN 可有效将药物递送至真皮深层，并有效促进毛发生长。
结论
丁香酚-DMN 为治疗脱发患者提供了一种有前途的策略。
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