Yang Darun, Xu Hongyan, Zhang Xuejun, Hu Yuntao, Huang Decai, Zhao Huaiqing
School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong, 250022, P. R. China.
Org Biomol Chem. 2023 Aug 23;21(33):6750-6756. doi: 10.1039/d3ob00805c.
An external oxidant free Ru(II)-catalyzed C-H activation followed by an intermolecular annulation between oximes and sulfoxonium ylides has been developed. This transformation proceeds smoothly with a broad range of substrates, affording a series of isoquinoline derivatives in moderate to good yields. This protocol was successfully applied to the synthesis of moxaverine.
已开发出一种无外部氧化剂的Ru(II)催化的C-H活化反应，随后肟与亚砜叶立德之间发生分子间环化反应。该转化反应在广泛的底物上顺利进行，以中等至良好的产率得到一系列异喹啉衍生物。该方法已成功应用于莫沙维林的合成。
