Mehl Sarah T, Simmons Pamela M, Whittington Julie R, Escalona-Vargas Diana, Siegel Eric R, Lowery Curtis L, Crimmins-Pierce Lauren D, Eswaran Hari
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center, Houston, TX, USA.
Curr Res Physiol. 2023 Jul 21;6:100103. doi: 10.1016/j.crphys.2023.100103. eCollection 2023.
The purpose of this study was to determine if uterine electrophysiological signals gathered from 151 non-invasive biomagnetic sensors spread over the abdomen were associated with successful induction of labor (IOL).
Uterine magnetomyogram (MMG) signals were collected using the SARA (SQUID Array for Reproductive Assessment) device from 33 subjects between 37 and 42 weeks gestational age. The signals were post-processed, uterine contractile related MMG bursts were detected, and parameters in the time and frequency domain were extracted. The modified Bishop score calculated at admission was used to determine the method of IOL. Wilcoxon's rank-sum test was used to compare IOL successes and failures for differences in gestational age (GA), parity, modified Bishop's score, maximum oxytocin, and electrophysiological parameters extracted from MMG.
The average parity was three times (3x) higher (1.53 versus 0.50; p = 0.039), and the average modified Bishop score was 2x higher (3.32 versus 1.63; p = 0.032) amongst IOL successes than failures, while the average GA and maximum oxytocin showed a small difference. For the MMG parameters, successful IOLs had, on average, 3.5x greater mean power during bursts (0.246 versus 0.070; p = 0.034) and approximately 1.2x greater mean number of bursts (2.05 versus 1.68; p = 0.036) compared to the failed IOLs, but non-significant differences were observed in mean peak frequency, mean burst duration, and mean duration between bursts.
The study showed that inductions of labor that took less than 24 h to deliver have a higher mean power in the baseline electrophysiological activity of the uterus when recorded prior to planned induction. The results are indicative that baseline electrophysiological activity measured prior to induction is associated with successful induction.
本研究旨在确定从分布于腹部的151个非侵入性生物磁传感器收集的子宫电生理信号是否与引产成功相关。
使用SARA（用于生殖评估的超导量子干涉仪阵列）设备收集了33名孕龄在37至42周之间的受试者的子宫磁肌电图（MMG）信号。对信号进行后处理，检测与子宫收缩相关的MMG猝发，并提取时域和频域参数。入院时计算的改良Bishop评分用于确定引产方法。采用Wilcoxon秩和检验比较引产成功与失败在孕龄（GA）、产次、改良Bishop评分、最大缩宫素以及从MMG提取的电生理参数方面的差异。
引产成功组的平均产次比失败组高3倍（1.53对0.50；p = 0.039），平均改良Bishop评分高2倍（3.32对1.63；p = 0.032），而平均孕龄和最大缩宫素差异较小。对于MMG参数，与引产失败组相比，引产成功组在猝发期间的平均功率平均高3.5倍（0.246对0.070；p = 0.034），平均猝发次数高约1.2倍（2.05对1.68；p = 0.036），但在平均峰值频率、平均猝发持续时间和猝发之间的平均持续时间方面未观察到显著差异。
该研究表明，计划引产之前记录的引产时间少于24小时的子宫基线电生理活动平均功率较高。结果表明引产之前测量的基线电生理活动与引产成功相关。
